Southwest® flights from Louisville to Des Moines from $177

Promo Code

Low fares from Louisville to Des Moines

$

Louisville (SDF)to

Des Moines (DSM)
Depart: 02/11/2027

One-way

Basic

From
$177
Seen: 5 hrs ago

Louisville (SDF)to

Des Moines (DSM)
Depart: 02/11/2027

One-way

Choice

From
$212
Seen: 5 hrs ago

Louisville (SDF)to

Des Moines (DSM)
Depart: 02/11/2027

One-way

Choice Preferred

From
$282
Seen: 5 hrs ago

Louisville (SDF)to

Des Moines (DSM)
Depart: 02/11/2027

One-way

Choice Extra

From
$322
Seen: 5 hrs ago

Louisville (SDF)to

Des Moines (DSM)
Depart: 11/19/2026

One-way

Choice

From
$341
Seen: 22 hrs ago

Louisville (SDF)to

Des Moines (DSM)
Depart: 11/20/2026

One-way

Choice

From
$341
Seen: 19 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Louisville to Des Moines

Nov 2026
From$341*
Seen: 22 hrs ago
One Way/Basic
Dec 2026
No result for this month.
Jan 2027
No result for this month.
cmp-daily-histogram-bars-legend-min-price-aria-label $341
Displaying fares for November-2026
  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    13

    Fri

    NOV

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    14

    Sat

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    15

    Sun

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    16

    Mon

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    17

    Tue

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    18

    Wed

  • SDF–DSM, 11/19/2026: From $341
    19

    Thu

  • SDF–DSM, 11/20/2026: From $341
    20

    Fri

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    21

    Sat

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    22

    Sun

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    23

    Mon

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    24

    Tue

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    25

    Wed

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    26

    Thu

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    27

    Fri

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    28

    Sat

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    29

    Sun

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    30

    Mon

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    01

    Tue

    DEC

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    02

    Wed

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    03

    Thu

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    04

    Fri

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    05

    Sat

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    06

    Sun

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    07

    Mon

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    08

    Tue

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    09

    Wed

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    10

    Thu

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    11

    Fri

  • SDF–DSM: cmp-view-offers-disclaimer. Find Offers
    12

    Sat

    • Range$341

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Louisville International Airport
    Arriving at:
    Des Moines Airport
    Distance:
    481 miles

    Questions we hear the most

    There are 28 weekly flights from Louisville to Des Moines on Southwest Airlines.
    To find the lowest fares by day and time to fly Louisville to Des Moines with Southwest, check out our Low Fare Calendar.
    You can rent a car at Des Moines Airport book yours with your flight.
    Yes! Flights from Louisville to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

    Explore Flights from Other Popular Origins

    Popular Flights from Louisville