Southwest® flights from Midland/Odessa to Knoxville from $163

Promo Code

Low fares from Midland/Odessa to Knoxville

$

Midland/Odessa (MAF)to

Knoxville (TYS)
Depart: 09/05/2026

One-way

Basic

From
$163

Low fares from Midland/Odessa to Knoxville

$

Midland/Odessa (MAF)to

Knoxville (TYS)
Depart: 09/05/2026

One-way

Basic

From
$163
Seen: 23 hrs ago

Midland/Odessa (MAF)to

Knoxville (TYS)
Depart: 09/10/2026

One-way

Basic

From
$187
Seen: 1 hour ago

Midland/Odessa (MAF)to

Knoxville (TYS)
Depart: 09/05/2026

One-way

Choice

From
$208
Seen: 23 hrs ago

Midland/Odessa (MAF)to

Knoxville (TYS)
Depart: 09/11/2026

One-way

Basic

From
$209
Seen: 1 hour ago

Midland/Odessa (MAF)to

Knoxville (TYS)
Depart: 09/10/2026

One-way

Choice

From
$232
Seen: 1 hour ago

Midland/Odessa (MAF)to

Knoxville (TYS)
Depart: 09/11/2026

One-way

Choice

From
$254
Seen: 1 hour ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Midland/Odessa to Knoxville

Jun 2026
From$384*
Seen: 4 hrs ago
One Way/Basic
Jul 2026
From$279*
Seen: 4 hrs ago
One Way/Basic
Aug 2026
No result for this month.
cmp-daily-histogram-bars-legend-min-price-aria-label $279
cmp-daily-histogram-bars-legend-max-price-aria-label $437
Displaying fares for June-2026
  • 24

    Wed

    JUN

  • 25

    Thu

  • 26

    Fri

  • 27

    Sat

  • 28

    Sun

  • 29

    Mon

  • 30

    Tue

  • 01

    Wed

    JUL

  • 02

    Thu

  • 03

    Fri

  • 04

    Sat

  • 05

    Sun

  • 06

    Mon

  • 07

    Tue

  • 08

    Wed

  • 09

    Thu

  • 10

    Fri

  • 11

    Sat

  • 12

    Sun

  • 13

    Mon

  • 14

    Tue

  • 15

    Wed

  • 16

    Thu

  • 17

    Fri

  • 18

    Sat

  • 19

    Sun

  • 20

    Mon

  • 21

    Tue

  • 22

    Wed

  • 23

    Thu

    • Range$279-$437

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Midland International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    1078 miles

    Route Information

    32† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 32 weekly flights from Midland/Odessa to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Midland/Odessa to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Midland/Odessa to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

    Explore Flights from Other Popular Origins

    Popular Flights from Midland/Odessa