Southwest® flights from New Orleans to Knoxville from $144

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Low fares from New Orleans to Knoxville

$

New Orleans (MSY)to

Knoxville (TYS)
Depart: 02/27/2027

One-way

Basic

From
$144

Low fares from New Orleans to Knoxville

$

New Orleans (MSY)to

Knoxville (TYS)
Depart: 12/12/2026

One-way

Basic

From
$144
Seen: 12 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 11/26/2026

One-way

Basic

From
$144
Seen: 12 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 12/08/2026

One-way

Basic

From
$144
Seen: 7 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 12/11/2026

One-way

Basic

From
$144
Seen: 12 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 12/01/2026

One-way

Basic

From
$144
Seen: 22 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 12/09/2026

One-way

Basic

From
$144
Seen: 7 hrs ago

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Explore flights from New Orleans to Knoxville

Nov 2026
From$144*
Seen: 12 hrs ago
One Way/Basic
Dec 2026
From$144*
Seen: 12 hrs ago
One Way/Basic
Jan 2027
From$144*
Seen: 9 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $144
cmp-daily-histogram-bars-legend-max-price-aria-label $636
Displaying fares for November-2026
  • MSY–TYS: cmp-view-offers-disclaimer. Find Offers
    01

    Sun

    NOV

  • MSY–TYS, 11/02/2026: From $335
    02

    Mon

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    03

    Tue

  • MSY–TYS, 11/04/2026: From $260
    04

    Wed

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    05

    Thu

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    06

    Fri

  • MSY–TYS, 11/07/2026: From $267
    07

    Sat

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    08

    Sun

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    09

    Mon

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    10

    Tue

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    11

    Wed

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    12

    Thu

  • MSY–TYS, 11/13/2026: From $279
    13

    Fri

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    14

    Sat

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    15

    Sun

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    16

    Mon

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    17

    Tue

  • MSY–TYS: cmp-view-offers-disclaimer. Find Offers
    18

    Wed

  • MSY–TYS, 11/19/2026: From $333
    19

    Thu

  • MSY–TYS: cmp-view-offers-disclaimer. Find Offers
    20

    Fri

  • MSY–TYS, 11/21/2026: From $214
    21

    Sat

  • MSY–TYS: cmp-view-offers-disclaimer. Find Offers
    22

    Sun

  • MSY–TYS, 11/23/2026: From $225
    23

    Mon

  • MSY–TYS, 11/24/2026: From $209
    24

    Tue

  • MSY–TYS, 11/25/2026: From $214
    25

    Wed

  • MSY–TYS, 11/26/2026: From $144
    26

    Thu

  • MSY–TYS: cmp-view-offers-disclaimer. Find Offers
    27

    Fri

  • MSY–TYS: cmp-view-offers-disclaimer. Find Offers
    28

    Sat

  • MSY–TYS, 11/29/2026: From $636
    29

    Sun

  • MSY–TYS: cmp-view-offers-disclaimer. Find Offers
    30

    Mon

    • Range$144-$636

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Louis Armstrong International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    541 miles

    Questions we hear the most

    There are 71 weekly flights from New Orleans to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly New Orleans to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from New Orleans to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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