Southwest® flights from New Orleans to Knoxville from $144

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Low fares from New Orleans to Knoxville

$

New Orleans (MSY)to

Knoxville (TYS)
Depart: 11/11/2026

One-way

Basic

From
$144

Low fares from New Orleans to Knoxville

$

New Orleans (MSY)to

Knoxville (TYS)
Depart: 11/11/2026

One-way

Basic

From
$144
Seen: 20 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 11/17/2026

One-way

Basic

From
$144
Seen: 17 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 10/13/2026

One-way

Basic

From
$149
Seen: 2 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 12/11/2026

One-way

Basic

From
$155
Seen: 3 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 11/17/2026

One-way

Choice

From
$184
Seen: 17 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 11/11/2026

One-way

Choice

From
$184
Seen: 20 hrs ago

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Explore flights from New Orleans to Knoxville

Sep 2026
From$250*
Seen: 22 hrs ago
One Way/Basic
Oct 2026
From$149*
Seen: 2 hrs ago
One Way/Basic
Nov 2026
From$144*
Seen: 17 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $149
Displaying fares for September-2026
  • MSY–TYS, 09/21/2026: From $325
    21

    Mon

    SEP

  • MSY–TYS: cmp-view-offers-disclaimer. Find Offers
    22

    Tue

  • MSY–TYS, 09/23/2026: From $250
    23

    Wed

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    24

    Thu

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    25

    Fri

  • MSY–TYS, 09/26/2026: From $257
    26

    Sat

  • MSY–TYS, 09/27/2026: From $325
    27

    Sun

  • MSY–TYS, 09/28/2026: From $330
    28

    Mon

  • MSY–TYS, 09/29/2026: From $250
    29

    Tue

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    30

    Wed

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    01

    Thu

    OCT

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    02

    Fri

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    03

    Sat

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    04

    Sun

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    05

    Mon

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    06

    Tue

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    07

    Wed

  • MSY–TYS, 10/08/2026: From $254
    08

    Thu

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    09

    Fri

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    10

    Sat

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    11

    Sun

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    12

    Mon

  • MSY–TYS, 10/13/2026: From $149
    13

    Tue

  • MSY–TYS: cmp-view-offers-disclaimer. Find Offers
    14

    Wed

  • MSY–TYS: cmp-view-offers-disclaimer. Find Offers
    15

    Thu

  • MSY–TYS, 10/16/2026: From $284
    16

    Fri

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    17

    Sat

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    18

    Sun

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    19

    Mon

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    20

    Tue

    • Range$149-$330

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Louis Armstrong International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    541 miles

    Route Information

    71† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 71 weekly flights from New Orleans to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly New Orleans to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from New Orleans to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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