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Southwest® flights from New Orleans to Knoxville from $148

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Low fares from New Orleans to Knoxville

$

New Orleans (MSY)to

Knoxville (TYS)
Depart: 05/26/2026

One-way

Basic

From
$148

Low fares from New Orleans to Knoxville

$

New Orleans (MSY)to

Knoxville (TYS)
Depart: 05/26/2026

One-way

Basic

From
$148
Seen: 13 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 05/27/2026

One-way

Basic

From
$148
Seen: 12 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 06/30/2026

One-way

Basic

From
$148
Seen: 5 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 07/01/2026

One-way

Basic

From
$153
Seen: 5 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 05/23/2026

One-way

Basic

From
$166
Seen: 8 hrs ago

New Orleans (MSY)to

Knoxville (TYS)
Depart: 06/04/2026

One-way

Basic

From
$174
Seen: 1 hour ago

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Explore flights from New Orleans to Knoxville

May 2026
From$148*
Seen: 13 hrs ago
One Way/Basic
Jun 2026
From$148*
Seen: 5 hrs ago
One Way/Basic
Jul 2026
From$153*
Seen: 5 hrs ago
One Way/Basic
$148
$344
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    • Range$148-$344

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Louis Armstrong International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    541 miles

    Route Information

    71† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 71 weekly flights from New Orleans to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly New Orleans to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from New Orleans to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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