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Find low faresSouthwest® flights from Orange County/Santa Ana to Buffalo/Niagara Falls from $223
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1 Passenger
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Low fares from Orange County/Santa Ana to Buffalo/Niagara Falls
$
Orange County/Santa Ana (SNA)to
Buffalo/Niagara Falls (BUF)
Depart: 02/24/2026
One-way
Basic
From
$223
Seen: 13 hrs ago
Orange County/Santa Ana (SNA)to
Buffalo/Niagara Falls (BUF)
Depart: 04/08/2026
One-way
Basic
From
$239
Seen: 54 minutes ago
Orange County/Santa Ana (SNA)to
Buffalo/Niagara Falls (BUF)
Depart: 02/24/2026
One-way
Choice
From
$263
Seen: 13 hrs ago
Orange County/Santa Ana (SNA)to
Buffalo/Niagara Falls (BUF)
Depart: 04/08/2026
One-way
Choice
From
$279
Seen: 54 minutes ago
Orange County/Santa Ana (SNA)to
Buffalo/Niagara Falls (BUF)
Depart: 03/01/2026
One-way
Basic
From
$290
Seen: 13 hrs ago
Orange County/Santa Ana (SNA)to
Buffalo/Niagara Falls (BUF)
Depart: 02/21/2026
One-way
Basic
From
$295
Seen: 17 hrs ago
Explore flights from Orange County/Santa Ana to Buffalo/Niagara Falls
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Flight Details
Departing from:
John Wayne Airport
Arriving at:
Buffalo Niagara International Airport
Distance:
2199 miles
Route Information
53† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 53 weekly flights from Orange County/Santa Ana to Buffalo/Niagara Falls on Southwest Airlines.
To find the lowest fares by day and time to fly Orange County/Santa Ana to Buffalo/Niagara Falls with Southwest, check out our Low Fare Calendar.
You can rent a car at Buffalo Niagara International Airport book yours with your flight.
Yes! Flights from Orange County/Santa Ana to Buffalo/Niagara Falls—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.