Southwest® flights from Orange County/Santa Ana to Buffalo/Niagara Falls from $219

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Low fares from Orange County/Santa Ana to Buffalo/Niagara Falls

$

Orange County/Santa Ana (SNA)to

Buffalo/Niagara Falls (BUF)
Depart: 11/17/2026

One-way

Basic

From
$219
Seen: 1 hour ago

Orange County/Santa Ana (SNA)to

Buffalo/Niagara Falls (BUF)
Depart: 10/27/2026

One-way

Basic

From
$219
Seen: 16 hrs ago

Orange County/Santa Ana (SNA)to

Buffalo/Niagara Falls (BUF)
Depart: 10/26/2026

One-way

Basic

From
$224
Seen: 19 hrs ago

Orange County/Santa Ana (SNA)to

Buffalo/Niagara Falls (BUF)
Depart: 11/11/2026

One-way

Basic

From
$224
Seen: 11 hrs ago

Orange County/Santa Ana (SNA)to

Buffalo/Niagara Falls (BUF)
Depart: 10/20/2026

One-way

Basic

From
$235
Seen: 20 hrs ago

Orange County/Santa Ana (SNA)to

Buffalo/Niagara Falls (BUF)
Depart: 10/30/2026

One-way

Basic

From
$235
Seen: 13 hrs ago

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Explore flights from Orange County/Santa Ana to Buffalo/Niagara Falls

Oct 2026
From$219*
Seen: 16 hrs ago
One Way/Basic
Nov 2026
From$219*
Seen: 1 hour ago
One Way/Basic
Dec 2026
From$265*
Seen: 23 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $219
cmp-daily-histogram-bars-legend-max-price-aria-label $527
Displaying fares for October-2026
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  • SNA–BUF, 10/09/2026: From $527
    09

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    16

    Fri

  • SNA–BUF, 10/17/2026: From $335
    17

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    18

    Sun

  • SNA–BUF: cmp-view-offers-disclaimer. Find Offers
    19

    Mon

  • SNA–BUF, 10/20/2026: From $235
    20

    Tue

  • SNA–BUF: cmp-view-offers-disclaimer. Find Offers
    21

    Wed

  • SNA–BUF, 10/22/2026: From $260
    22

    Thu

  • SNA–BUF, 10/23/2026: From $240
    23

    Fri

  • SNA–BUF, 10/24/2026: From $240
    24

    Sat

  • SNA–BUF, 10/25/2026: From $310
    25

    Sun

  • SNA–BUF, 10/26/2026: From $224
    26

    Mon

  • SNA–BUF, 10/27/2026: From $219
    27

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    28

    Wed

  • SNA–BUF: cmp-view-offers-disclaimer. Find Offers
    29

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  • SNA–BUF, 10/30/2026: From $235
    30

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  • SNA–BUF: cmp-view-offers-disclaimer. Find Offers
    31

    Sat

    • Range$219-$527

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    John Wayne Airport
    Arriving at:
    Buffalo Niagara International Airport
    Distance:
    2199 miles

    Route Information

    53† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 53 weekly flights from Orange County/Santa Ana to Buffalo/Niagara Falls on Southwest Airlines.
    To find the lowest fares by day and time to fly Orange County/Santa Ana to Buffalo/Niagara Falls with Southwest, check out our Low Fare Calendar.
    You can rent a car at Buffalo Niagara International Airport book yours with your flight.
    Yes! Flights from Orange County/Santa Ana to Buffalo/Niagara Falls—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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