Southwest® flights from Orange County/Santa Ana to Des Moines from $193

Promo Code

Low fares from Orange County/Santa Ana to Des Moines

$

Orange County/Santa Ana (SNA)to

Des Moines (DSM)
Depart: 10/06/2026

One-way

Basic

From
$193
Seen: 1 hour ago

Orange County/Santa Ana (SNA)to

Des Moines (DSM)
Depart: 10/07/2026

One-way

Basic

From
$193
Seen: 4 hrs ago

Orange County/Santa Ana (SNA)to

Des Moines (DSM)
Depart: 09/24/2026

One-way

Basic

From
$234
Seen: 7 hrs ago

Orange County/Santa Ana (SNA)to

Des Moines (DSM)
Depart: 10/06/2026

One-way

Choice

From
$238
Seen: 1 hour ago

Orange County/Santa Ana (SNA)to

Des Moines (DSM)
Depart: 10/08/2026

One-way

Basic

From
$238
Seen: 17 hrs ago

Orange County/Santa Ana (SNA)to

Des Moines (DSM)
Depart: 10/07/2026

One-way

Choice

From
$238
Seen: 4 hrs ago

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Explore flights from Orange County/Santa Ana to Des Moines

Aug 2026
From$289*
Seen: 8 hrs ago
One Way/Basic
Sep 2026
From$234*
Seen: 7 hrs ago
One Way/Basic
Oct 2026
From$193*
Seen: 4 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $289
Displaying fares for August-2026
  • SNA–DSM: cmp-view-offers-disclaimer. Find Offers
    02

    Sun

    AUG

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    03

    Mon

  • SNA–DSM, 08/04/2026: From $549
    04

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  • SNA–DSM, 08/05/2026: From $549
    05

    Wed

  • SNA–DSM, 08/06/2026: From $549
    06

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  • SNA–DSM, 08/09/2026: From $459
    09

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  • SNA–DSM, 08/10/2026: From $459
    10

    Mon

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    11

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    12

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  • SNA–DSM, 08/13/2026: From $459
    13

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  • SNA–DSM, 08/14/2026: From $459
    14

    Fri

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    15

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    16

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  • SNA–DSM, 08/17/2026: From $289
    17

    Mon

  • SNA–DSM, 08/18/2026: From $289
    18

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    19

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    21

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    24

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    26

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    27

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    30

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    SEP

    • Range$289-$549

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    John Wayne Airport
    Arriving at:
    Des Moines Airport
    Distance:
    1429 miles

    Route Information

    66† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 66 weekly flights from Orange County/Santa Ana to Des Moines on Southwest Airlines.
    To find the lowest fares by day and time to fly Orange County/Santa Ana to Des Moines with Southwest, check out our Low Fare Calendar.
    You can rent a car at Des Moines Airport book yours with your flight.
    Yes! Flights from Orange County/Santa Ana to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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