Southwest® flights from Pittsburgh to Knoxville from $159

Promo Code
Knoxville

Visit Knoxville


Book your flight to Knoxville and explore mountain views, live music, and nearby adventures in Gatlinburg and Pigeon Forge.

Flights available to book today. Service starts March 5, 2026.

Find flights

Low fares from Pittsburgh to Knoxville

$

Pittsburgh (PIT)to

Knoxville (TYS)
Depart: 09/09/2026

One-way

Basic

From
$154

Low fares from Pittsburgh to Knoxville

$

Pittsburgh (PIT)to

Knoxville (TYS)
Depart: 03/09/2026

One-way

Basic

From
$159
Seen: 6 hrs ago

Pittsburgh (PIT)to

Knoxville (TYS)
Depart: 04/16/2026

One-way

Basic

From
$159
Seen: 4 hrs ago

Pittsburgh (PIT)to

Knoxville (TYS)
Depart: 03/05/2026

One-way

Basic

From
$169
Seen: 6 hrs ago

Pittsburgh (PIT)to

Knoxville (TYS)
Depart: 04/24/2026

One-way

Basic

From
$169
Seen: 16 hrs ago

Pittsburgh (PIT)to

Knoxville (TYS)
Depart: 03/09/2026

One-way

Choice

From
$189
Seen: 6 hrs ago

Pittsburgh (PIT)to

Knoxville (TYS)
Depart: 04/16/2026

One-way

Choice

From
$189
Seen: 4 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Pittsburgh to Knoxville

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Pittsburgh International Airport
Arriving at:
Mc Ghee Tyson Airport
Distance:
382 miles

Route Information

50† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 50 weekly flights from Pittsburgh to Knoxville on Southwest Airlines.
To find the lowest fares by day and time to fly Pittsburgh to Knoxville with Southwest, check out our Low Fare Calendar.
You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
Yes! Flights from Pittsburgh to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

Explore Flights from Other Popular Origins

Popular Flights from Pittsburgh