Southwest® flights from Portland, OR to Knoxville from $161

Promo Code

Low fares from Portland, OR to Knoxville

$

Portland, OR (PDX)to

Knoxville (TYS)
Depart: 11/09/2026

One-way

Basic

From
$161

Low fares from Portland, OR to Knoxville

$

Portland, OR (PDX)to

Knoxville (TYS)
Depart: 11/09/2026

One-way

Basic

From
$161
Seen: 18 hrs ago

Portland, OR (PDX)to

Knoxville (TYS)
Depart: 11/18/2026

One-way

Basic

From
$161
Seen: 19 hrs ago

Portland, OR (PDX)to

Knoxville (TYS)
Depart: 11/09/2026

One-way

Choice

From
$218
Seen: 18 hrs ago

Portland, OR (PDX)to

Knoxville (TYS)
Depart: 11/18/2026

One-way

Choice

From
$218
Seen: 19 hrs ago

Portland, OR (PDX)to

Knoxville (TYS)
Depart: 11/18/2026

One-way

Choice Preferred

From
$302
Seen: 19 hrs ago

Portland, OR (PDX)to

Knoxville (TYS)
Depart: 11/09/2026

One-way

Choice Preferred

From
$302
Seen: 18 hrs ago

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Explore flights from Portland, OR to Knoxville

Oct 2026
From$444*
Seen: 18 hrs ago
One Way/Basic
Nov 2026
From$161*
Seen: 19 hrs ago
One Way/Basic
Dec 2026
No result for this month.
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Displaying fares for October-2026
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  • PDX–TYS, 10/26/2026: From $444
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  • PDX–TYS, 11/01/2026: From $397
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  • PDX–TYS, 11/09/2026: From $161
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  • PDX–TYS, 11/18/2026: From $161
    18

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  • PDX–TYS, 11/20/2026: From $489
    20

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    • Range$161-$489

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Portland International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    2113 miles

    Questions we hear the most

    There are 31 weekly flights from Portland, OR to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Portland, OR to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Portland, OR to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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