Southwest® flights from San Diego to Knoxville from $182

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Low fares from San Diego to Knoxville

$

San Diego (SAN)to

Knoxville (TYS)
Depart: 10/27/2026

One-way

Basic

From
$182

Low fares from San Diego to Knoxville

$

San Diego (SAN)to

Knoxville (TYS)
Depart: 10/27/2026

One-way

Basic

From
$182
Seen: 23 hrs ago

San Diego (SAN)to

Knoxville (TYS)
Depart: 11/11/2026

One-way

Basic

From
$182
Seen: 20 hrs ago

San Diego (SAN)to

Knoxville (TYS)
Depart: 10/26/2026

One-way

Basic

From
$187
Seen: 23 hrs ago

San Diego (SAN)to

Knoxville (TYS)
Depart: 11/25/2026

One-way

Basic

From
$191
Seen: 44 minutes ago

San Diego (SAN)to

Knoxville (TYS)
Depart: 11/07/2026

One-way

Basic

From
$206
Seen: 10 hrs ago

San Diego (SAN)to

Knoxville (TYS)
Depart: 11/12/2026

One-way

Basic

From
$219
Seen: 10 minutes ago

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Explore flights from San Diego to Knoxville

Oct 2026
From$182*
Seen: 23 hrs ago
One Way/Basic
Nov 2026
From$182*
Seen: 20 hrs ago
One Way/Basic
Dec 2026
From$223*
Seen: 7 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $182
Displaying fares for October-2026
  • SAN–TYS, 10/03/2026: From $691
    03

    Sat

    OCT

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    04

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  • SAN–TYS, 10/06/2026: From $420
    06

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    07

    Wed

  • SAN–TYS, 10/08/2026: From $539
    08

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    Fri

  • SAN–TYS, 10/10/2026: From $484
    10

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    11

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  • SAN–TYS, 10/12/2026: From $386
    12

    Mon

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    25

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  • SAN–TYS, 10/26/2026: From $187
    26

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  • SAN–TYS, 10/27/2026: From $182
    27

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    28

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    30

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    NOV

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    • Range$182-$691

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    San Diego International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    1902 miles

    Route Information

    48† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 48 weekly flights from San Diego to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly San Diego to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from San Diego to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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