Southwest® flights from San Francisco to Knoxville from $253

Promo Code
Knoxville

Visit Knoxville


Book your flight to Knoxville and explore mountain views, live music, and nearby adventures in Gatlinburg and Pigeon Forge.

Flights available to book today. Service starts March 5, 2026.

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Low fares from San Francisco to Knoxville

$

San Francisco (SFO)to

Knoxville (TYS)
Depart: 05/02/2026

One-way

Basic

From
$253

Low fares from San Francisco to Knoxville

$

San Francisco (SFO)to

Knoxville (TYS)
Depart: 05/02/2026

One-way

Basic

From
$253
Seen: 23 hrs ago

San Francisco (SFO)to

Knoxville (TYS)
Depart: 05/02/2026

One-way

Choice

From
$293
Seen: 23 hrs ago

San Francisco (SFO)to

Knoxville (TYS)
Depart: 03/05/2026

One-way

Basic

From
$335
Seen: 22 hrs ago

San Francisco (SFO)to

Knoxville (TYS)
Depart: 03/22/2026

One-way

Basic

From
$335
Seen: 18 hrs ago

San Francisco (SFO)to

Knoxville (TYS)
Depart: 05/02/2026

One-way

Choice Preferred

From
$373
Seen: 23 hrs ago

San Francisco (SFO)to

Knoxville (TYS)
Depart: 03/05/2026

One-way

Choice

From
$374
Seen: 22 hrs ago

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Explore flights from San Francisco to Knoxville

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
San Francisco International Airport
Arriving at:
Mc Ghee Tyson Airport
Distance:
2120 miles

Route Information

34† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 34 weekly flights from San Francisco to Knoxville on Southwest Airlines.
To find the lowest fares by day and time to fly San Francisco to Knoxville with Southwest, check out our Low Fare Calendar.
You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
Yes! Flights from San Francisco to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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