Southwest® flights from Tampa to Knoxville from $107

Promo Code

Low fares from Tampa to Knoxville

$

Tampa (TPA)to

Knoxville (TYS)
Depart: 04/21/2026

One-way

Basic

From
$107

Low fares from Tampa to Knoxville

$

Tampa (TPA)to

Knoxville (TYS)
Depart: 04/21/2026

One-way

Basic

From
$107
Seen: 2 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 04/14/2026

One-way

Basic

From
$116
Seen: 1 hour ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 06/06/2026

One-way

Basic

From
$127
Seen: 57 minutes ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 05/16/2026

One-way

Basic

From
$132
Seen: 2 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 04/21/2026

One-way

Choice

From
$146
Seen: 2 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 04/14/2026

One-way

Choice

From
$157
Seen: 1 hour ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Tampa to Knoxville

Mar 2026
From$176*
Seen: 7 hrs ago
One Way/Basic
Apr 2026
From$107*
Seen: 2 hrs ago
One Way/Basic
May 2026
From$132*
Seen: 2 hrs ago
One Way/Basic
$107
$256
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    • Range$107-$256

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Tampa International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    547 miles

    Route Information

    55† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 55 weekly flights from Tampa to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Tampa to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Tampa to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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