Southwest® flights from Tampa to Knoxville from $109

Promo Code

Low fares from Tampa to Knoxville

$

Tampa (TPA)to

Knoxville (TYS)
Depart: 12/03/2026

One-way

Basic

From
$109

Low fares from Tampa to Knoxville

$

Tampa (TPA)to

Knoxville (TYS)
Depart: 12/03/2026

One-way

Basic

From
$109
Seen: 23 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 01/09/2027

One-way

Basic

From
$109
Seen: 5 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 12/01/2026

One-way

Basic

From
$109
Seen: 6 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 12/05/2026

One-way

Basic

From
$109
Seen: 19 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 12/16/2026

One-way

Basic

From
$109
Seen: 18 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 01/07/2027

One-way

Basic

From
$109
Seen: 23 hrs ago

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Explore flights from Tampa to Knoxville

Try alternate month or interact with individual days below in order to find offers.
Oct 2026
No result for this month.
Nov 2026
From$109*
Seen: 1 hour ago
One Way/Basic
Dec 2026
From$109*
Seen: 19 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $109
cmp-daily-histogram-bars-legend-max-price-aria-label $349
Displaying fares for October-2026
  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    31

    Sat

    OCT

  • TPA–TYS, 11/01/2026: From $349
    01

    Sun

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    02

    Mon

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    03

    Tue

  • TPA–TYS, 11/04/2026: From $349
    04

    Wed

  • TPA–TYS, 11/05/2026: From $349
    05

    Thu

  • TPA–TYS, 11/06/2026: From $349
    06

    Fri

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    07

    Sat

  • TPA–TYS, 11/08/2026: From $349
    08

    Sun

  • TPA–TYS, 11/09/2026: From $344
    09

    Mon

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    10

    Tue

  • TPA–TYS, 11/11/2026: From $344
    11

    Wed

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    12

    Thu

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    13

    Fri

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    14

    Sat

  • TPA–TYS, 11/15/2026: From $278
    15

    Sun

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    16

    Mon

  • TPA–TYS, 11/17/2026: From $250
    17

    Tue

  • TPA–TYS, 11/18/2026: From $250
    18

    Wed

  • TPA–TYS, 11/19/2026: From $250
    19

    Thu

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    20

    Fri

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    21

    Sat

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    22

    Sun

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    23

    Mon

  • TPA–TYS, 11/24/2026: From $159
    24

    Tue

  • TPA–TYS, 11/25/2026: From $114
    25

    Wed

  • TPA–TYS, 11/26/2026: From $109
    26

    Thu

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    27

    Fri

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    28

    Sat

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    29

    Sun

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    30

    Mon

    • Range$109-$349

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Tampa International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    547 miles

    Questions we hear the most

    There are 55 weekly flights from Tampa to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Tampa to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Tampa to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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