Southwest® flights from Tampa to Knoxville from $109

Promo Code

Low fares from Tampa to Knoxville

$

Tampa (TPA)to

Knoxville (TYS)
Depart: 01/06/2027

One-way

Basic

From
$109

Low fares from Tampa to Knoxville

$

Tampa (TPA)to

Knoxville (TYS)
Depart: 12/03/2026

One-way

Basic

From
$109
Seen: 23 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 11/17/2026

One-way

Basic

From
$109
Seen: 3 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 11/17/2026

One-way

Choice

From
$149
Seen: 3 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 12/03/2026

One-way

Choice

From
$149
Seen: 23 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 12/04/2026

One-way

Basic

From
$149
Seen: 9 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 11/26/2026

One-way

Basic

From
$158
Seen: 21 hrs ago

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Explore flights from Tampa to Knoxville

Sep 2026
From$353*
Seen: 18 hrs ago
One Way/Basic
Oct 2026
From$176*
Seen: 2 hrs ago
One Way/Basic
Nov 2026
From$109*
Seen: 3 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $190
cmp-daily-histogram-bars-legend-max-price-aria-label $468
Displaying fares for September-2026
  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    20

    Sun

    SEP

  • TPA–TYS, 09/21/2026: From $353
    21

    Mon

  • TPA–TYS, 09/22/2026: From $353
    22

    Tue

  • TPA–TYS, 09/23/2026: From $353
    23

    Wed

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    24

    Thu

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    25

    Fri

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    26

    Sat

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    27

    Sun

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    28

    Mon

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    29

    Tue

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    30

    Wed

  • TPA–TYS, 10/01/2026: From $339
    01

    Thu

    OCT

  • TPA–TYS, 10/02/2026: From $339
    02

    Fri

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    03

    Sat

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    04

    Sun

  • TPA–TYS, 10/05/2026: From $240
    05

    Mon

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    06

    Tue

  • TPA–TYS, 10/07/2026: From $310
    07

    Wed

  • TPA–TYS, 10/08/2026: From $318
    08

    Thu

  • TPA–TYS, 10/09/2026: From $468
    09

    Fri

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    10

    Sat

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    11

    Sun

  • TPA–TYS, 10/12/2026: From $230
    12

    Mon

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    13

    Tue

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    14

    Wed

  • TPA–TYS, 10/15/2026: From $329
    15

    Thu

  • TPA–TYS, 10/16/2026: From $315
    16

    Fri

  • TPA–TYS, 10/17/2026: From $190
    17

    Sat

  • TPA–TYS, 10/18/2026: From $240
    18

    Sun

  • TPA–TYS, 10/19/2026: From $208
    19

    Mon

    • Range$190-$468

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Tampa International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    547 miles

    Route Information

    55† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 55 weekly flights from Tampa to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Tampa to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Tampa to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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