Southwest® flights from Tampa to Knoxville from $99

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Low fares from Tampa to Knoxville

$

Tampa (TPA)to

Knoxville (TYS)
Depart: 12/19/2026

One-way

Basic

From
$99

Low fares from Tampa to Knoxville

$

Tampa (TPA)to

Knoxville (TYS)
Depart: 12/19/2026

One-way

Basic

From
$99
Seen: 10 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 12/04/2026

One-way

Basic

From
$109
Seen: 7 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 11/11/2026

One-way

Basic

From
$109
Seen: 12 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 12/25/2026

One-way

Basic

From
$109
Seen: 42 minutes ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 12/08/2026

One-way

Basic

From
$109
Seen: 3 hrs ago

Tampa (TPA)to

Knoxville (TYS)
Depart: 12/11/2026

One-way

Basic

From
$109
Seen: 17 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

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Explore flights from Tampa to Knoxville

Oct 2026
From$240*
Seen: 2 hrs ago
One Way/Basic
Nov 2026
From$109*
Seen: 12 hrs ago
One Way/Basic
Dec 2026
From$99*
Seen: 10 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $109
cmp-daily-histogram-bars-legend-max-price-aria-label $344
Displaying fares for October-2026
  • TPA–TYS, 10/11/2026: From $339
    11

    Sun

    OCT

  • TPA–TYS, 10/12/2026: From $344
    12

    Mon

  • TPA–TYS, 10/13/2026: From $339
    13

    Tue

  • TPA–TYS, 10/14/2026: From $339
    14

    Wed

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    15

    Thu

  • TPA–TYS, 10/16/2026: From $344
    16

    Fri

  • TPA–TYS, 10/17/2026: From $334
    17

    Sat

  • TPA–TYS, 10/18/2026: From $334
    18

    Sun

  • TPA–TYS, 10/19/2026: From $334
    19

    Mon

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    20

    Tue

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    21

    Wed

  • TPA–TYS, 10/22/2026: From $334
    22

    Thu

  • TPA–TYS, 10/23/2026: From $334
    23

    Fri

  • TPA–TYS, 10/24/2026: From $240
    24

    Sat

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    25

    Sun

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    26

    Mon

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    27

    Tue

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    28

    Wed

  • TPA–TYS, 10/29/2026: From $245
    29

    Thu

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    30

    Fri

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    31

    Sat

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    01

    Sun

    NOV

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    02

    Mon

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    03

    Tue

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    04

    Wed

  • TPA–TYS, 11/05/2026: From $257
    05

    Thu

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    06

    Fri

  • TPA–TYS, 11/07/2026: From $114
    07

    Sat

  • TPA–TYS, 11/08/2026: From $168
    08

    Sun

  • TPA–TYS: cmp-view-offers-disclaimer. Find Offers
    09

    Mon

  • TPA–TYS, 11/10/2026: From $109
    10

    Tue

    • Range$109-$344

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Tampa International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    547 miles

    Questions we hear the most

    There are 55 weekly flights from Tampa to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Tampa to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Tampa to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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