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Find low faresSouthwest® flights from Buffalo/Niagara Falls to Greenville-Spartanburg from $152
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Low fares from Buffalo/Niagara Falls to Greenville-Spartanburg
$
Buffalo/Niagara Falls (BUF)to
Greenville-Spartanburg (GSP)
Depart: 04/18/2026
One-way
Basic
From
$152
Seen: 20 hrs ago
Buffalo/Niagara Falls (BUF)to
Greenville-Spartanburg (GSP)
Depart: 02/28/2026
One-way
Basic
From
$170
Seen: 49 minutes ago
Buffalo/Niagara Falls (BUF)to
Greenville-Spartanburg (GSP)
Depart: 03/20/2026
One-way
Basic
From
$184
Seen: 3 hrs ago
Buffalo/Niagara Falls (BUF)to
Greenville-Spartanburg (GSP)
Depart: 03/07/2026
One-way
Basic
From
$184
Seen: 1 hour ago
Buffalo/Niagara Falls (BUF)to
Greenville-Spartanburg (GSP)
Depart: 03/21/2026
One-way
Basic
From
$184
Seen: 8 hrs ago
Buffalo/Niagara Falls (BUF)to
Greenville-Spartanburg (GSP)
Depart: 04/09/2026
One-way
Basic
From
$184
Seen: 7 hrs ago
Explore flights from Buffalo/Niagara Falls to Greenville-Spartanburg
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Flight Details
Departing from:
Buffalo Niagara International Airport
Arriving at:
Greenville-Spartanburg International Airport
Distance:
586 miles
Route Information
52† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 52 weekly flights from Buffalo/Niagara Falls to Greenville-Spartanburg on Southwest Airlines.
To find the lowest fares by day and time to fly Buffalo/Niagara Falls to Greenville-Spartanburg with Southwest, check out our Low Fare Calendar.
You can rent a car at Greenville-Spartanburg International Airport book yours with your flight.
Yes! Flights from Buffalo/Niagara Falls to Greenville-Spartanburg—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.