Southwest® flights from Buffalo/Niagara Falls to Greenville-Spartanburg from $136

Promo Code

Low fares from Buffalo/Niagara Falls to Greenville-Spartanburg

$

Buffalo/Niagara Falls (BUF)to

Greenville-Spartanburg (GSP)
Depart: 03/31/2026

One-way

Basic

From
$136
Seen: 19 hrs ago

Buffalo/Niagara Falls (BUF)to

Greenville-Spartanburg (GSP)
Depart: 03/24/2026

One-way

Basic

From
$170
Seen: 16 hrs ago

Buffalo/Niagara Falls (BUF)to

Greenville-Spartanburg (GSP)
Depart: 03/31/2026

One-way

Choice

From
$171
Seen: 19 hrs ago

Buffalo/Niagara Falls (BUF)to

Greenville-Spartanburg (GSP)
Depart: 03/17/2026

One-way

Basic

From
$175
Seen: 14 hrs ago

Buffalo/Niagara Falls (BUF)to

Greenville-Spartanburg (GSP)
Depart: 05/06/2026

One-way

Basic

From
$175
Seen: 19 hrs ago

Buffalo/Niagara Falls (BUF)to

Greenville-Spartanburg (GSP)
Depart: 04/10/2026

One-way

Basic

From
$184
Seen: 18 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Buffalo/Niagara Falls to Greenville-Spartanburg

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Buffalo Niagara International Airport
Arriving at:
Greenville-Spartanburg International Airport
Distance:
586 miles

Route Information

52† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 52 weekly flights from Buffalo/Niagara Falls to Greenville-Spartanburg on Southwest Airlines.
To find the lowest fares by day and time to fly Buffalo/Niagara Falls to Greenville-Spartanburg with Southwest, check out our Low Fare Calendar.
You can rent a car at Greenville-Spartanburg International Airport book yours with your flight.
Yes! Flights from Buffalo/Niagara Falls to Greenville-Spartanburg—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

Explore Flights from Other Popular Origins

Popular Flights from Buffalo/Niagara Falls