Southwest® flights from Chicago (Midway) to Knoxville from $105

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Knoxville

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Book your flight to Knoxville and explore mountain views, live music, and nearby adventures in Gatlinburg and Pigeon Forge.

Flights available to book today. Service starts March 5, 2026.

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Low fares from Chicago (Midway) to Knoxville

$

Chicago (Midway) (MDW)to

Knoxville (TYS)
Depart: 06/30/2026

One-way

Basic

From
$105

Low fares from Chicago (Midway) to Knoxville

$

Chicago (Midway) (MDW)to

Knoxville (TYS)
Depart: 04/01/2026

One-way

Basic

From
$105
Seen: 1 hour ago

Chicago (Midway) (MDW)to

Knoxville (TYS)
Depart: 04/18/2026

One-way

Basic

From
$105
Seen: 21 hrs ago

Chicago (Midway) (MDW)to

Knoxville (TYS)
Depart: 05/02/2026

One-way

Basic

From
$105
Seen: 23 hrs ago

Chicago (Midway) (MDW)to

Knoxville (TYS)
Depart: 05/06/2026

One-way

Basic

From
$105
Seen: 4 hrs ago

Chicago (Midway) (MDW)to

Knoxville (TYS)
Depart: 04/04/2026

One-way

Basic

From
$105
Seen: 36 minutes ago

Chicago (Midway) (MDW)to

Knoxville (TYS)
Depart: 04/25/2026

One-way

Basic

From
$105
Seen: 20 minutes ago

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Explore flights from Chicago (Midway) to Knoxville

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Chicago Midway International Airport
Arriving at:
Mc Ghee Tyson Airport
Distance:
459 miles

Route Information

71† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 71 weekly flights from Chicago (Midway) to Knoxville on Southwest Airlines.
To find the lowest fares by day and time to fly Chicago (Midway) to Knoxville with Southwest, check out our Low Fare Calendar.
You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
Yes! Flights from Chicago (Midway) to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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