Southwest® flights from Chicago (Midway) to Knoxville from $150

Promo Code

Low fares from Chicago (Midway) to Knoxville

$

Chicago (Midway) (MDW)to

Knoxville (TYS)
Depart: 09/19/2026

One-way

Basic

From
$150

Low fares from Chicago (Midway) to Knoxville

$

Chicago (Midway) (MDW)to

Knoxville (TYS)
Depart: 09/19/2026

One-way

Basic

From
$150
Seen: 19 hrs ago

Chicago (Midway) (MDW)to

Knoxville (TYS)
Depart: 09/23/2026

One-way

Basic

From
$150
Seen: 11 hrs ago

Chicago (Midway) (MDW)to

Knoxville (TYS)
Depart: 10/17/2026

One-way

Basic

From
$150
Seen: 22 hrs ago

Chicago (Midway) (MDW)to

Knoxville (TYS)
Depart: 12/03/2026

One-way

Basic

From
$150
Seen: 22 hrs ago

Chicago (Midway) (MDW)to

Knoxville (TYS)
Depart: 11/10/2026

One-way

Basic

From
$150
Seen: 5 hrs ago

Chicago (Midway) (MDW)to

Knoxville (TYS)
Depart: 09/30/2026

One-way

Basic

From
$150
Seen: 2 hrs ago

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Explore flights from Chicago (Midway) to Knoxville

Aug 2026
From$250*
Seen: 1 hour ago
One Way/Basic
Sep 2026
From$150*
Seen: 2 hrs ago
One Way/Basic
Oct 2026
From$150*
Seen: 3 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $150
cmp-daily-histogram-bars-legend-max-price-aria-label $250
Displaying fares for August-2026
  • MDW–TYS, 08/31/2026: From $250
    31

    Mon

    AUG

  • MDW–TYS, 09/01/2026: From $210
    01

    Tue

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    02

    Wed

  • MDW–TYS, 09/03/2026: From $250
    03

    Thu

  • MDW–TYS, 09/04/2026: From $250
    04

    Fri

  • MDW–TYS, 09/05/2026: From $210
    05

    Sat

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    06

    Sun

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    07

    Mon

  • MDW–TYS, 09/08/2026: From $195
    08

    Tue

  • MDW–TYS, 09/09/2026: From $175
    09

    Wed

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    10

    Thu

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    11

    Fri

  • MDW–TYS, 09/12/2026: From $165
    12

    Sat

  • MDW–TYS, 09/13/2026: From $215
    13

    Sun

  • MDW–TYS, 09/14/2026: From $165
    14

    Mon

  • MDW–TYS, 09/15/2026: From $165
    15

    Tue

  • MDW–TYS, 09/16/2026: From $165
    16

    Wed

  • MDW–TYS, 09/17/2026: From $215
    17

    Thu

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    18

    Fri

  • MDW–TYS, 09/19/2026: From $150
    19

    Sat

  • MDW–TYS, 09/20/2026: From $194
    20

    Sun

  • MDW–TYS, 09/21/2026: From $165
    21

    Mon

  • MDW–TYS, 09/22/2026: From $150
    22

    Tue

  • MDW–TYS, 09/23/2026: From $150
    23

    Wed

  • MDW–TYS, 09/24/2026: From $250
    24

    Thu

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    25

    Fri

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    26

    Sat

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    27

    Sun

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    28

    Mon

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    29

    Tue

  • MDW–TYS, 09/30/2026: From $150
    30

    Wed

    • Range$150-$250

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Chicago Midway International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    459 miles

    Route Information

    71† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 71 weekly flights from Chicago (Midway) to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Chicago (Midway) to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Chicago (Midway) to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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