Southwest® flights from Chicago-Midway to Knoxville from $121

Promo Code

Low fares from Chicago-Midway to Knoxville

$

Chicago-Midway (MDW)to

Knoxville (TYS)
Depart: 02/20/2027

One-way

Basic

From
$116

Low fares from Chicago-Midway to Knoxville

$

Chicago-Midway (MDW)to

Knoxville (TYS)
Depart: 12/05/2026

One-way

Basic

From
$121
Seen: 16 hrs ago

Chicago-Midway (MDW)to

Knoxville (TYS)
Depart: 12/08/2026

One-way

Basic

From
$121
Seen: 22 hrs ago

Chicago-Midway (MDW)to

Knoxville (TYS)
Depart: 12/15/2026

One-way

Basic

From
$121
Seen: 15 hrs ago

Chicago-Midway (MDW)to

Knoxville (TYS)
Depart: 12/04/2026

One-way

Basic

From
$133
Seen: 15 hrs ago

Chicago-Midway (MDW)to

Knoxville (TYS)
Depart: 01/22/2027

One-way

Basic

From
$133
Seen: 9 hrs ago

Chicago-Midway (MDW)to

Knoxville (TYS)
Depart: 12/11/2026

One-way

Basic

From
$133
Seen: 2 hrs ago

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Explore flights from Chicago-Midway to Knoxville

Oct 2026
From$230*
Seen: 5 hrs ago
One Way/Basic
Nov 2026
From$170*
Seen: 22 hrs ago
One Way/Basic
Dec 2026
From$121*
Seen: 16 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $170
cmp-daily-histogram-bars-legend-max-price-aria-label $614
Displaying fares for October-2026
  • MDW–TYS, 10/31/2026: From $230
    31

    Sat

    OCT

  • MDW–TYS, 11/01/2026: From $270
    01

    Sun

  • MDW–TYS, 11/02/2026: From $270
    02

    Mon

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    03

    Tue

  • MDW–TYS, 11/04/2026: From $230
    04

    Wed

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    05

    Thu

  • MDW–TYS, 11/06/2026: From $275
    06

    Fri

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    07

    Sat

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    08

    Sun

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    09

    Mon

  • MDW–TYS, 11/10/2026: From $215
    10

    Tue

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    11

    Wed

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    12

    Thu

  • MDW–TYS, 11/13/2026: From $190
    13

    Fri

  • MDW–TYS, 11/14/2026: From $185
    14

    Sat

  • MDW–TYS, 11/15/2026: From $310
    15

    Sun

  • MDW–TYS, 11/16/2026: From $185
    16

    Mon

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    17

    Tue

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    18

    Wed

  • MDW–TYS, 11/19/2026: From $287
    19

    Thu

  • MDW–TYS, 11/20/2026: From $364
    20

    Fri

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    21

    Sat

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    22

    Sun

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    23

    Mon

  • MDW–TYS, 11/24/2026: From $196
    24

    Tue

  • MDW–TYS, 11/25/2026: From $185
    25

    Wed

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    26

    Thu

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    27

    Fri

  • MDW–TYS, 11/28/2026: From $170
    28

    Sat

  • MDW–TYS, 11/29/2026: From $614
    29

    Sun

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    30

    Mon

    • Range$170-$614

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Chicago Midway International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    459 miles

    Questions we hear the most

    There are 71 weekly flights from Chicago (Midway) to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Chicago (Midway) to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Chicago (Midway) to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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