Southwest® flights from Chicago-Midway to Knoxville from $137

Promo Code

Low fares from Chicago-Midway to Knoxville

$

Chicago-Midway (MDW)to

Knoxville (TYS)
Depart: 01/16/2027

One-way

Basic

From
$137

Low fares from Chicago-Midway to Knoxville

$

Chicago-Midway (MDW)to

Knoxville (TYS)
Depart: 12/10/2026

One-way

Basic

From
$137
Seen: 20 hrs ago

Chicago-Midway (MDW)to

Knoxville (TYS)
Depart: 12/17/2026

One-way

Basic

From
$137
Seen: 10 hrs ago

Chicago-Midway (MDW)to

Knoxville (TYS)
Depart: 12/24/2026

One-way

Basic

From
$137
Seen: 11 hrs ago

Chicago-Midway (MDW)to

Knoxville (TYS)
Depart: 11/14/2026

One-way

Basic

From
$137
Seen: 2 hrs ago

Chicago-Midway (MDW)to

Knoxville (TYS)
Depart: 12/08/2026

One-way

Basic

From
$137
Seen: 34 minutes ago

Chicago-Midway (MDW)to

Knoxville (TYS)
Depart: 11/17/2026

One-way

Basic

From
$137
Seen: 19 hrs ago

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Explore flights from Chicago-Midway to Knoxville

Sep 2026
From$205*
Seen: 10 hrs ago
One Way/Basic
Oct 2026
From$137*
Seen: 10 hrs ago
One Way/Basic
Nov 2026
From$137*
Seen: 8 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $142
cmp-daily-histogram-bars-legend-max-price-aria-label $416
Displaying fares for September-2026
  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    20

    Sun

    SEP

  • MDW–TYS, 09/21/2026: From $260
    21

    Mon

  • MDW–TYS, 09/22/2026: From $225
    22

    Tue

  • MDW–TYS, 09/23/2026: From $237
    23

    Wed

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    24

    Thu

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    25

    Fri

  • MDW–TYS, 09/26/2026: From $205
    26

    Sat

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    27

    Sun

  • MDW–TYS, 09/28/2026: From $205
    28

    Mon

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    29

    Tue

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    30

    Wed

  • MDW–TYS, 10/01/2026: From $288
    01

    Thu

    OCT

  • MDW–TYS, 10/02/2026: From $265
    02

    Fri

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    03

    Sat

  • MDW–TYS, 10/04/2026: From $225
    04

    Sun

  • MDW–TYS, 10/05/2026: From $205
    05

    Mon

  • MDW–TYS, 10/06/2026: From $175
    06

    Tue

  • MDW–TYS, 10/07/2026: From $210
    07

    Wed

  • MDW–TYS, 10/08/2026: From $369
    08

    Thu

  • MDW–TYS, 10/09/2026: From $255
    09

    Fri

  • MDW–TYS, 10/10/2026: From $277
    10

    Sat

  • MDW–TYS, 10/11/2026: From $416
    11

    Sun

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    12

    Mon

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    13

    Tue

  • MDW–TYS, 10/14/2026: From $142
    14

    Wed

  • MDW–TYS, 10/15/2026: From $283
    15

    Thu

  • MDW–TYS, 10/16/2026: From $277
    16

    Fri

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    17

    Sat

  • MDW–TYS, 10/18/2026: From $219
    18

    Sun

  • MDW–TYS: cmp-view-offers-disclaimer. Find Offers
    19

    Mon

    • Range$142-$416

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Chicago Midway International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    459 miles

    Route Information

    71† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 71 weekly flights from Chicago (Midway) to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Chicago (Midway) to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Chicago (Midway) to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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