Southwest® flights from Denver to Knoxville from $145

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Low fares from Denver to Knoxville

$

Denver (DEN)to

Knoxville (TYS)
Depart: 12/14/2026

One-way

Basic

From
$145

Low fares from Denver to Knoxville

$

Denver (DEN)to

Knoxville (TYS)
Depart: 11/10/2026

One-way

Basic

From
$145
Seen: 18 hrs ago

Denver (DEN)to

Knoxville (TYS)
Depart: 11/09/2026

One-way

Basic

From
$155
Seen: 8 hrs ago

Denver (DEN)to

Knoxville (TYS)
Depart: 09/21/2026

One-way

Basic

From
$155
Seen: 6 hrs ago

Denver (DEN)to

Knoxville (TYS)
Depart: 09/15/2026

One-way

Basic

From
$155
Seen: 7 hrs ago

Denver (DEN)to

Knoxville (TYS)
Depart: 09/22/2026

One-way

Basic

From
$155
Seen: 7 hrs ago

Denver (DEN)to

Knoxville (TYS)
Depart: 09/26/2026

One-way

Basic

From
$155
Seen: 2 hrs ago

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Explore flights from Denver to Knoxville

Aug 2026
From$359*
Seen: 2 hrs ago
One Way/Basic
Sep 2026
From$155*
Seen: 6 hrs ago
One Way/Basic
Oct 2026
From$170*
Seen: 9 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $155
cmp-daily-histogram-bars-legend-max-price-aria-label $384
Displaying fares for August-2026
  • DEN–TYS, 08/24/2026: From $384
    24

    Mon

    AUG

  • DEN–TYS, 08/25/2026: From $384
    25

    Tue

  • DEN–TYS, 08/26/2026: From $384
    26

    Wed

  • DEN–TYS, 08/27/2026: From $384
    27

    Thu

  • DEN–TYS, 08/28/2026: From $384
    28

    Fri

  • DEN–TYS: cmp-view-offers-disclaimer. Find Offers
    29

    Sat

  • DEN–TYS: cmp-view-offers-disclaimer. Find Offers
    30

    Sun

  • DEN–TYS, 08/31/2026: From $359
    31

    Mon

  • DEN–TYS: cmp-view-offers-disclaimer. Find Offers
    01

    Tue

    SEP

  • DEN–TYS: cmp-view-offers-disclaimer. Find Offers
    02

    Wed

  • DEN–TYS, 09/03/2026: From $369
    03

    Thu

  • DEN–TYS, 09/04/2026: From $369
    04

    Fri

  • DEN–TYS, 09/05/2026: From $359
    05

    Sat

  • DEN–TYS: cmp-view-offers-disclaimer. Find Offers
    06

    Sun

  • DEN–TYS, 09/07/2026: From $274
    07

    Mon

  • DEN–TYS, 09/08/2026: From $274
    08

    Tue

  • DEN–TYS, 09/09/2026: From $264
    09

    Wed

  • DEN–TYS, 09/10/2026: From $274
    10

    Thu

  • DEN–TYS: cmp-view-offers-disclaimer. Find Offers
    11

    Fri

  • DEN–TYS, 09/12/2026: From $264
    12

    Sat

  • DEN–TYS, 09/13/2026: From $225
    13

    Sun

  • DEN–TYS, 09/14/2026: From $170
    14

    Mon

  • DEN–TYS, 09/15/2026: From $155
    15

    Tue

  • DEN–TYS, 09/16/2026: From $175
    16

    Wed

  • DEN–TYS, 09/17/2026: From $284
    17

    Thu

  • DEN–TYS, 09/18/2026: From $299
    18

    Fri

  • DEN–TYS: cmp-view-offers-disclaimer. Find Offers
    19

    Sat

  • DEN–TYS, 09/20/2026: From $225
    20

    Sun

  • DEN–TYS, 09/21/2026: From $155
    21

    Mon

  • DEN–TYS, 09/22/2026: From $155
    22

    Tue

  • DEN–TYS: cmp-view-offers-disclaimer. Find Offers
    23

    Wed

    • Range$155-$384

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Denver International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Average flight time:
    2 hours 47 minutes
    Distance:
    1162 miles

    Route Information

    67† Weekly flights
    • 1‡ Nonstop flight on Saturday
    • 1‡ Nonstop flight on Sunday

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    The average flight time from Denver to Knoxville is 2 hours 47 minutes.
    There are 67 weekly flights from Denver to Knoxville on Southwest Airlines.
    Yes, Southwest flies nonstop from Denver to Knoxville once per day on Saturdays and Sundays.
    To find the lowest fares by day and time to fly Denver to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Denver to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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