Southwest® flights from Denver to Knoxville from $152

Promo Code

Low fares from Denver to Knoxville

$

Denver (DEN)to

Knoxville (TYS)
Depart: 05/09/2026

One-way

Basic

From
$152

Low fares from Denver to Knoxville

$

Denver (DEN)to

Knoxville (TYS)
Depart: 05/09/2026

One-way

Basic

From
$152
Seen: 10 hrs ago

Denver (DEN)to

Knoxville (TYS)
Depart: 05/12/2026

One-way

Basic

From
$162
Seen: 10 hrs ago

Denver (DEN)to

Knoxville (TYS)
Depart: 04/28/2026

One-way

Basic

From
$162
Seen: 5 hrs ago

Denver (DEN)to

Knoxville (TYS)
Depart: 05/16/2026

One-way

Basic

From
$167
Seen: 10 hrs ago

Denver (DEN)to

Knoxville (TYS)
Depart: 06/03/2026

One-way

Basic

From
$167
Seen: 7 hrs ago

Denver (DEN)to

Knoxville (TYS)
Depart: 06/02/2026

One-way

Basic

From
$167
Seen: 12 hrs ago

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Explore flights from Denver to Knoxville

Mar 2026
From$269*
Seen: 8 hrs ago
One Way/Basic
Apr 2026
From$162*
Seen: 5 hrs ago
One Way/Basic
May 2026
From$152*
Seen: 10 hrs ago
One Way/Basic
$173
$344
Displaying fares for March-2026
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    • Range$173-$344

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Denver International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Average flight time:
    2 hours 47 minutes
    Distance:
    1162 miles

    Route Information

    67† Weekly flights
    • 1‡ Nonstop flight on Saturday
    • 1‡ Nonstop flight on Sunday

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    The average flight time from Denver to Knoxville is 2 hours 47 minutes.
    There are 67 weekly flights from Denver to Knoxville on Southwest Airlines.
    Yes, Southwest flies nonstop from Denver to Knoxville once per day on Saturdays and Sundays.
    To find the lowest fares by day and time to fly Denver to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Denver to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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