Southwest® flights from Detroit to San Antonio from $225

Promo Code

Low fares from Detroit to San Antonio

$

Detroit (DTW)to

San Antonio (SAT)
Depart: 11/24/2026

One-way

Basic

From
$225
Seen: 23 hrs ago

Detroit (DTW)to

San Antonio (SAT)
Depart: 11/26/2026

One-way

Basic

From
$235
Seen: 23 hrs ago

Detroit (DTW)to

San Antonio (SAT)
Depart: 10/15/2026

One-way

Basic

From
$235
Seen: 21 hrs ago

Detroit (DTW)to

San Antonio (SAT)
Depart: 10/13/2026

One-way

Basic

From
$235
Seen: 16 hrs ago

Detroit (DTW)to

San Antonio (SAT)
Depart: 10/27/2026

One-way

Basic

From
$235
Seen: 12 hrs ago

Detroit (DTW)to

San Antonio (SAT)
Depart: 11/27/2026

One-way

Basic

From
$235
Seen: 3 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Detroit to San Antonio

Sep 2026
From$335*
Seen: 20 hrs ago
One Way/Basic
Oct 2026
From$235*
Seen: 16 hrs ago
One Way/Basic
Nov 2026
From$225*
Seen: 23 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $261
cmp-daily-histogram-bars-legend-max-price-aria-label $450
Displaying fares for September-2026
  • DTW–SAT, 09/12/2026: From $450
    12

    Sat

    SEP

  • DTW–SAT: cmp-view-offers-disclaimer. Find Offers
    13

    Sun

  • DTW–SAT, 09/14/2026: From $450
    14

    Mon

  • DTW–SAT, 09/15/2026: From $450
    15

    Tue

  • DTW–SAT, 09/16/2026: From $450
    16

    Wed

  • DTW–SAT: cmp-view-offers-disclaimer. Find Offers
    17

    Thu

  • DTW–SAT, 09/18/2026: From $385
    18

    Fri

  • DTW–SAT: cmp-view-offers-disclaimer. Find Offers
    19

    Sat

  • DTW–SAT: cmp-view-offers-disclaimer. Find Offers
    20

    Sun

  • DTW–SAT: cmp-view-offers-disclaimer. Find Offers
    21

    Mon

  • DTW–SAT, 09/22/2026: From $385
    22

    Tue

  • DTW–SAT, 09/23/2026: From $385
    23

    Wed

  • DTW–SAT: cmp-view-offers-disclaimer. Find Offers
    24

    Thu

  • DTW–SAT, 09/25/2026: From $335
    25

    Fri

  • DTW–SAT: cmp-view-offers-disclaimer. Find Offers
    26

    Sat

  • DTW–SAT, 09/27/2026: From $345
    27

    Sun

  • DTW–SAT, 09/28/2026: From $335
    28

    Mon

  • DTW–SAT, 09/29/2026: From $335
    29

    Tue

  • DTW–SAT: cmp-view-offers-disclaimer. Find Offers
    30

    Wed

  • DTW–SAT, 10/01/2026: From $335
    01

    Thu

    OCT

  • DTW–SAT: cmp-view-offers-disclaimer. Find Offers
    02

    Fri

  • DTW–SAT, 10/03/2026: From $261
    03

    Sat

  • DTW–SAT, 10/04/2026: From $285
    04

    Sun

  • DTW–SAT: cmp-view-offers-disclaimer. Find Offers
    05

    Mon

  • DTW–SAT: cmp-view-offers-disclaimer. Find Offers
    06

    Tue

  • DTW–SAT, 10/07/2026: From $261
    07

    Wed

  • DTW–SAT, 10/08/2026: From $261
    08

    Thu

  • DTW–SAT: cmp-view-offers-disclaimer. Find Offers
    09

    Fri

  • DTW–SAT: cmp-view-offers-disclaimer. Find Offers
    10

    Sat

  • DTW–SAT: cmp-view-offers-disclaimer. Find Offers
    11

    Sun

    • Range$261-$450

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Wayne County Airport
    Arriving at:
    San Antonio International Airport
    Distance:
    1214 miles

    Route Information

    115† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 115 weekly flights from Detroit to San Antonio on Southwest Airlines.
    To find the lowest fares by day and time to fly Detroit to San Antonio with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Antonio International Airport book yours with your flight.
    Yes! Flights from Detroit to San Antonio—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

    Explore Flights from Other Popular Origins

    Popular Flights from Detroit