Southwest® flights from Detroit to St. Louis from $79

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Low fares from Detroit to St. Louis

$

Detroit (DTW)to

St. Louis (STL)
Depart: 09/26/2026

One-way

Basic

From
$79
Seen: 3 hrs ago

Detroit (DTW)to

St. Louis (STL)
Depart: 09/23/2026

One-way

Basic

From
$79
Seen: 3 hrs ago

Detroit (DTW)to

St. Louis (STL)
Depart: 09/22/2026

One-way

Basic

From
$84
Seen: 13 hrs ago

Detroit (DTW)to

St. Louis (STL)
Depart: 09/12/2026

One-way

Basic

From
$84
Seen: 5 hrs ago

Detroit (DTW)to

St. Louis (STL)
Depart: 09/29/2026

One-way

Basic

From
$84
Seen: 6 hrs ago

Detroit (DTW)to

St. Louis (STL)
Depart: 09/23/2026

One-way

Choice

From
$114
Seen: 3 hrs ago

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Explore flights from Detroit to St. Louis

Aug 2026
From$340*
Seen: 17 hrs ago
One Way/Basic
Sep 2026
From$79*
Seen: 3 hrs ago
One Way/Basic
Oct 2026
From$129*
Seen: 5 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $84
cmp-daily-histogram-bars-legend-max-price-aria-label $417
Displaying fares for August-2026
  • DTW–STL, 08/22/2026: From $417
    22

    Sat

    AUG

  • DTW–STL, 08/23/2026: From $417
    23

    Sun

  • DTW–STL, 08/24/2026: From $417
    24

    Mon

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    25

    Tue

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    26

    Wed

  • DTW–STL, 08/27/2026: From $417
    27

    Thu

  • DTW–STL, 08/28/2026: From $340
    28

    Fri

  • DTW–STL, 08/29/2026: From $340
    29

    Sat

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    30

    Sun

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    31

    Mon

  • DTW–STL, 09/01/2026: From $340
    01

    Tue

    SEP

  • DTW–STL, 09/02/2026: From $340
    02

    Wed

  • DTW–STL, 09/03/2026: From $340
    03

    Thu

  • DTW–STL, 09/04/2026: From $228
    04

    Fri

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    05

    Sat

  • DTW–STL, 09/06/2026: From $228
    06

    Sun

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    07

    Mon

  • DTW–STL, 09/08/2026: From $228
    08

    Tue

  • DTW–STL, 09/09/2026: From $228
    09

    Wed

  • DTW–STL, 09/10/2026: From $228
    10

    Thu

  • DTW–STL, 09/11/2026: From $134
    11

    Fri

  • DTW–STL, 09/12/2026: From $84
    12

    Sat

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    13

    Sun

  • DTW–STL, 09/14/2026: From $154
    14

    Mon

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    15

    Tue

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    16

    Wed

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    17

    Thu

  • DTW–STL, 09/18/2026: From $134
    18

    Fri

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    19

    Sat

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    20

    Sun

  • DTW–STL, 09/21/2026: From $139
    21

    Mon

    • Range$84-$417

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Wayne County Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Average flight time:
    1 hour 38 minutes
    Distance:
    440 miles

    Route Information

    125† Weekly flights
    • 1‡ Nonstop flight per day Monday through Friday
    • 1‡ Nonstop flight on Saturday
    • 2‡ Nonstop flights on Sunday

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    The average flight time from Detroit to St. Louis is 1 hour 38 minutes.
    There are 125 weekly flights from Detroit to St. Louis on Southwest Airlines.
    Yes, Southwest flies nonstop from Detroit to St. Louis once per day from Monday through Friday.
    Yes, Southwest flies nonstop from Detroit to St. Louis once per day on Saturdays and 2 times per day on Sundays.
    To find the lowest fares by day and time to fly Detroit to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from Detroit to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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