Southwest® flights from Detroit to St. Louis from $139

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Low fares from Detroit to St. Louis

$

Detroit (DTW)to

St. Louis (STL)
Depart: 11/25/2026

One-way

Basic

From
$139
Seen: 9 hrs ago

Detroit (DTW)to

St. Louis (STL)
Depart: 12/05/2026

One-way

Basic

From
$139
Seen: 15 hrs ago

Detroit (DTW)to

St. Louis (STL)
Depart: 10/29/2026

One-way

Basic

From
$139
Seen: 10 hrs ago

Detroit (DTW)to

St. Louis (STL)
Depart: 11/02/2026

One-way

Basic

From
$139
Seen: 5 hrs ago

Detroit (DTW)to

St. Louis (STL)
Depart: 11/19/2026

One-way

Basic

From
$139
Seen: 18 hrs ago

Detroit (DTW)to

St. Louis (STL)
Depart: 01/11/2027

One-way

Basic

From
$139
Seen: 14 hrs ago

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Explore flights from Detroit to St. Louis

Oct 2026
From$139*
Seen: 10 hrs ago
One Way/Basic
Nov 2026
From$139*
Seen: 5 hrs ago
One Way/Basic
Dec 2026
From$139*
Seen: 17 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $139
cmp-daily-histogram-bars-legend-max-price-aria-label $437
Displaying fares for October-2026
  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    03

    Sat

    OCT

  • DTW–STL, 10/04/2026: From $437
    04

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    05

    Mon

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    06

    Tue

  • DTW–STL, 10/07/2026: From $437
    07

    Wed

  • DTW–STL, 10/08/2026: From $437
    08

    Thu

  • DTW–STL, 10/09/2026: From $360
    09

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  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    10

    Sat

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    11

    Sun

  • DTW–STL, 10/12/2026: From $360
    12

    Mon

  • DTW–STL, 10/13/2026: From $360
    13

    Tue

  • DTW–STL, 10/14/2026: From $360
    14

    Wed

  • DTW–STL, 10/15/2026: From $248
    15

    Thu

  • DTW–STL, 10/16/2026: From $248
    16

    Fri

  • DTW–STL, 10/17/2026: From $248
    17

    Sat

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    18

    Sun

  • DTW–STL, 10/19/2026: From $248
    19

    Mon

  • DTW–STL, 10/20/2026: From $248
    20

    Tue

  • DTW–STL, 10/21/2026: From $248
    21

    Wed

  • DTW–STL, 10/22/2026: From $248
    22

    Thu

  • DTW–STL, 10/23/2026: From $181
    23

    Fri

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    24

    Sat

  • DTW–STL, 10/25/2026: From $206
    25

    Sun

  • DTW–STL, 10/26/2026: From $181
    26

    Mon

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    27

    Tue

  • DTW–STL, 10/28/2026: From $139
    28

    Wed

  • DTW–STL, 10/29/2026: From $139
    29

    Thu

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    30

    Fri

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    31

    Sat

  • DTW–STL: cmp-view-offers-disclaimer. Find Offers
    01

    Sun

    NOV

  • DTW–STL, 11/02/2026: From $139
    02

    Mon

    • Range$139-$437

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Wayne County Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Average flight time:
    1 hour 38 minutes
    Distance:
    440 miles

    Route Information

    125† Weekly flights
    • 1‡ Nonstop flight per day Monday through Friday
    • 1‡ Nonstop flight on Saturday
    • 2‡ Nonstop flights on Sunday

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    The average flight time from Detroit to St. Louis is 1 hour 38 minutes.
    There are 125 weekly flights from Detroit to St. Louis on Southwest Airlines.
    Yes, Southwest flies nonstop from Detroit to St. Louis once per day from Monday through Friday.
    Yes, Southwest flies nonstop from Detroit to St. Louis once per day on Saturdays and 2 times per day on Sundays.
    To find the lowest fares by day and time to fly Detroit to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from Detroit to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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