Southwest® flights from Fort Myers/Naples to Knoxville from $130

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Knoxville

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Book your flight to Knoxville and explore mountain views, live music, and nearby adventures in Gatlinburg and Pigeon Forge.

Flights available to book today. Service starts March 5, 2026.

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Low fares from Fort Myers/Naples to Knoxville

$

Fort Myers/Naples (RSW)to

Knoxville (TYS)
Depart: 04/01/2026

One-way

Basic

From
$130

Low fares from Fort Myers/Naples to Knoxville

$

Fort Myers/Naples (RSW)to

Knoxville (TYS)
Depart: 04/01/2026

One-way

Basic

From
$130
Seen: 5 hrs ago

Fort Myers/Naples (RSW)to

Knoxville (TYS)
Depart: 04/01/2026

One-way

Choice

From
$165
Seen: 5 hrs ago

Fort Myers/Naples (RSW)to

Knoxville (TYS)
Depart: 03/06/2026

One-way

Basic

From
$174
Seen: 12 hrs ago

Fort Myers/Naples (RSW)to

Knoxville (TYS)
Depart: 03/26/2026

One-way

Basic

From
$189
Seen: 10 hrs ago

Fort Myers/Naples (RSW)to

Knoxville (TYS)
Depart: 04/23/2026

One-way

Basic

From
$194
Seen: 15 hrs ago

Fort Myers/Naples (RSW)to

Knoxville (TYS)
Depart: 03/06/2026

One-way

Choice

From
$209
Seen: 12 hrs ago

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Explore flights from Fort Myers/Naples to Knoxville

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Southwest Florida Regional Airport
Arriving at:
Mc Ghee Tyson Airport
Distance:
653 miles

Route Information

43† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 43 weekly flights from Fort Myers/Naples to Knoxville on Southwest Airlines.
To find the lowest fares by day and time to fly Fort Myers/Naples to Knoxville with Southwest, check out our Low Fare Calendar.
You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
Yes! Flights from Fort Myers/Naples to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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