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Find low faresSouthwest® flights from Greenville-Spartanburg to Buffalo/Niagara Falls from $224
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Low fares from Greenville-Spartanburg to Buffalo/Niagara Falls
$
Greenville-Spartanburg (GSP)to
Buffalo/Niagara Falls (BUF)
Depart: 02/16/2026
One-way
Basic
From
$224
Seen: 37 minutes ago
Greenville-Spartanburg (GSP)to
Buffalo/Niagara Falls (BUF)
Depart: 02/15/2026
One-way
Basic
From
$224
Seen: 37 minutes ago
Greenville-Spartanburg (GSP)to
Buffalo/Niagara Falls (BUF)
Depart: 02/16/2026
One-way
Choice
From
$259
Seen: 37 minutes ago
Greenville-Spartanburg (GSP)to
Buffalo/Niagara Falls (BUF)
Depart: 02/15/2026
One-way
Choice
From
$259
Seen: 37 minutes ago
Greenville-Spartanburg (GSP)to
Buffalo/Niagara Falls (BUF)
Depart: 02/10/2026
One-way
Basic
From
$289
Seen: 10 hrs ago
Greenville-Spartanburg (GSP)to
Buffalo/Niagara Falls (BUF)
Depart: 02/08/2026
One-way
Basic
From
$289
Seen: 7 hrs ago
Explore flights from Greenville-Spartanburg to Buffalo/Niagara Falls
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Flight Details
Departing from:
Greenville-Spartanburg International Airport
Arriving at:
Buffalo Niagara International Airport
Distance:
586 miles
Route Information
55† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 55 weekly flights from Greenville-Spartanburg to Buffalo/Niagara Falls on Southwest Airlines.
To find the lowest fares by day and time to fly Greenville-Spartanburg to Buffalo/Niagara Falls with Southwest, check out our Low Fare Calendar.
You can rent a car at Buffalo Niagara International Airport book yours with your flight.
Yes! Flights from Greenville-Spartanburg to Buffalo/Niagara Falls—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.