Southwest® flights from Milwaukee to Knoxville from $157

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Low fares from Milwaukee to Knoxville

$

Milwaukee (MKE)to

Knoxville (TYS)
Depart: 12/01/2026

One-way

Basic

From
$157

Low fares from Milwaukee to Knoxville

$

Milwaukee (MKE)to

Knoxville (TYS)
Depart: 12/01/2026

One-way

Basic

From
$157
Seen: 3 hrs ago

Milwaukee (MKE)to

Knoxville (TYS)
Depart: 12/11/2026

One-way

Basic

From
$157
Seen: 16 hrs ago

Milwaukee (MKE)to

Knoxville (TYS)
Depart: 12/17/2026

One-way

Basic

From
$157
Seen: 15 hrs ago

Milwaukee (MKE)to

Knoxville (TYS)
Depart: 11/22/2026

One-way

Basic

From
$185
Seen: 16 hrs ago

Milwaukee (MKE)to

Knoxville (TYS)
Depart: 12/01/2026

One-way

Choice

From
$197
Seen: 3 hrs ago

Milwaukee (MKE)to

Knoxville (TYS)
Depart: 12/11/2026

One-way

Choice

From
$197
Seen: 16 hrs ago

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Explore flights from Milwaukee to Knoxville

Nov 2026
From$185*
Seen: 16 hrs ago
One Way/Basic
Dec 2026
From$157*
Seen: 3 hrs ago
One Way/Basic
Jan 2027
From$234*
Seen: 52 minutes ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $185
cmp-daily-histogram-bars-legend-max-price-aria-label $399
Displaying fares for November-2026
  • MKE–TYS, 11/01/2026: From $382
    01

    Sun

    NOV

  • MKE–TYS: cmp-view-offers-disclaimer. Find Offers
    02

    Mon

  • MKE–TYS, 11/03/2026: From $382
    03

    Tue

  • MKE–TYS, 11/04/2026: From $382
    04

    Wed

  • MKE–TYS, 11/05/2026: From $387
    05

    Thu

  • MKE–TYS, 11/06/2026: From $399
    06

    Fri

  • MKE–TYS, 11/07/2026: From $229
    07

    Sat

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    08

    Sun

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    09

    Mon

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    10

    Tue

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    11

    Wed

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    12

    Thu

  • MKE–TYS, 11/13/2026: From $229
    13

    Fri

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    14

    Sat

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    15

    Sun

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    16

    Mon

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    17

    Tue

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    18

    Wed

  • MKE–TYS, 11/19/2026: From $289
    19

    Thu

  • MKE–TYS, 11/20/2026: From $355
    20

    Fri

  • MKE–TYS, 11/21/2026: From $224
    21

    Sat

  • MKE–TYS, 11/22/2026: From $185
    22

    Sun

  • MKE–TYS: cmp-view-offers-disclaimer. Find Offers
    23

    Mon

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    24

    Tue

  • MKE–TYS, 11/25/2026: From $224
    25

    Wed

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    26

    Thu

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    27

    Fri

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    28

    Sat

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    29

    Sun

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    30

    Mon

    • Range$185-$399

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    General Mitchell Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    535 miles

    Questions we hear the most

    There are 54 weekly flights from Milwaukee to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Milwaukee to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Milwaukee to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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