Southwest® flights from St. Louis to San Diego from $137

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Low fares from St. Louis to San Diego

$

St. Louis (STL)to

San Diego (SAN)
Depart: 11/18/2026

One-way

Basic

From
$137
Seen: 19 hrs ago

St. Louis (STL)to

San Diego (SAN)
Depart: 11/10/2026

One-way

Basic

From
$137
Seen: 15 hrs ago

St. Louis (STL)to

San Diego (SAN)
Depart: 12/08/2026

One-way

Basic

From
$137
Seen: 9 hrs ago

St. Louis (STL)to

San Diego (SAN)
Depart: 12/10/2026

One-way

Basic

From
$137
Seen: 4 hrs ago

St. Louis (STL)to

San Diego (SAN)
Depart: 12/16/2026

One-way

Basic

From
$137
Seen: 50 minutes ago

St. Louis (STL)to

San Diego (SAN)
Depart: 11/17/2026

One-way

Basic

From
$137
Seen: 19 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

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Explore flights from St. Louis to San Diego

Oct 2026
From$515*
Seen: 2 minutes ago
One Way/Basic
Nov 2026
From$137*
Seen: 19 hrs ago
One Way/Basic
Dec 2026
From$137*
Seen: 4 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $137
cmp-daily-histogram-bars-legend-max-price-aria-label $640
Displaying fares for October-2026
  • STL–SAN, 10/23/2026: From $640
    23

    Fri

    OCT

  • STL–SAN, 10/24/2026: From $635
    24

    Sat

  • STL–SAN, 10/25/2026: From $640
    25

    Sun

  • STL–SAN, 10/26/2026: From $640
    26

    Mon

  • STL–SAN, 10/27/2026: From $640
    27

    Tue

  • STL–SAN, 10/28/2026: From $640
    28

    Wed

  • STL–SAN, 10/29/2026: From $515
    29

    Thu

  • STL–SAN, 10/30/2026: From $558
    30

    Fri

  • STL–SAN, 10/31/2026: From $558
    31

    Sat

  • STL–SAN, 11/01/2026: From $558
    01

    Sun

    NOV

  • STL–SAN, 11/02/2026: From $558
    02

    Mon

  • STL–SAN: cmp-view-offers-disclaimer. Find Offers
    03

    Tue

  • STL–SAN, 11/04/2026: From $395
    04

    Wed

  • STL–SAN, 11/05/2026: From $400
    05

    Thu

  • STL–SAN, 11/06/2026: From $400
    06

    Fri

  • STL–SAN, 11/07/2026: From $400
    07

    Sat

  • STL–SAN, 11/08/2026: From $400
    08

    Sun

  • STL–SAN, 11/09/2026: From $142
    09

    Mon

  • STL–SAN, 11/10/2026: From $137
    10

    Tue

  • STL–SAN, 11/11/2026: From $186
    11

    Wed

  • STL–SAN, 11/12/2026: From $186
    12

    Thu

  • STL–SAN, 11/13/2026: From $177
    13

    Fri

  • STL–SAN, 11/14/2026: From $142
    14

    Sat

  • STL–SAN, 11/15/2026: From $349
    15

    Sun

  • STL–SAN, 11/16/2026: From $294
    16

    Mon

  • STL–SAN, 11/17/2026: From $137
    17

    Tue

  • STL–SAN, 11/18/2026: From $137
    18

    Wed

  • STL–SAN: cmp-view-offers-disclaimer. Find Offers
    19

    Thu

  • STL–SAN, 11/20/2026: From $205
    20

    Fri

  • STL–SAN, 11/21/2026: From $142
    21

    Sat

  • STL–SAN, 11/22/2026: From $177
    22

    Sun

    • Range$137-$640

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Lambert-St Louis Int'l Airport
    Arriving at:
    San Diego International Airport
    Average flight time:
    3 hours 54 minutes
    Distance:
    1557 miles

    Questions we hear the most

    The average flight time from St. Louis to San Diego is 3 hours 54 minutes.
    There are 157 weekly flights from St. Louis to San Diego on Southwest Airlines.
    Yes, Southwest flies nonstop from St. Louis to San Diego once per day from Monday through Friday.
    Yes, Southwest flies nonstop from St. Louis to San Diego once per day on Saturdays and 2 times per day on Sundays.
    To find the lowest fares by day and time to fly St. Louis to San Diego with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Diego International Airport book yours with your flight.
    Yes! Flights from St. Louis to San Diego—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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