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Find low faresSouthwest® flights from St. Louis to San Diego from $159
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Low fares from St. Louis to San Diego
$
St. Louis (STL)to
San Diego (SAN)
Depart: 05/06/2026
One-way
Basic
From
$154
Seen: 22 hrs ago
St. Louis (STL)to
San Diego (SAN)
Depart: 05/12/2026
One-way
Basic
From
$154
Seen: 8 hrs ago
St. Louis (STL)to
San Diego (SAN)
Depart: 04/09/2026
One-way
Basic
From
$159
Seen: 15 hrs ago
St. Louis (STL)to
San Diego (SAN)
Depart: 03/18/2026
One-way
Basic
From
$159
Seen: 23 hrs ago
St. Louis (STL)to
San Diego (SAN)
Depart: 04/10/2026
One-way
Basic
From
$159
Seen: 11 hrs ago
St. Louis (STL)to
San Diego (SAN)
Depart: 04/17/2026
One-way
Basic
From
$159
Seen: 8 hrs ago
Explore flights from St. Louis to San Diego
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Flight Details
Departing from:
Lambert-St Louis Int'l Airport
Arriving at:
San Diego International Airport
Average flight time:
3 hours 54 minutes
Distance:
1557 miles
Route Information
157† Weekly flights
- 1‡ Nonstop flight per day Monday through Friday
- 1‡ Nonstop flight on Saturday
- 2‡ Nonstop flights on Sunday
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
The average flight time from St. Louis to San Diego is 3 hours 54 minutes.
There are 157 weekly flights from St. Louis to San Diego on Southwest Airlines.
Yes, Southwest flies nonstop from St. Louis to San Diego once per day from Monday through Friday.
Yes, Southwest flies nonstop from St. Louis to San Diego once per day on Saturdays and 2 times per day on Sundays.
To find the lowest fares by day and time to fly St. Louis to San Diego with Southwest, check out our Low Fare Calendar.
You can rent a car at San Diego International Airport book yours with your flight.
Yes! Flights from St. Louis to San Diego—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.