Southwest® flights from Louisville to Knoxville from $133

Promo Code

Low fares from Louisville to Knoxville

$

Louisville (SDF)to

Knoxville (TYS)
Depart: 04/25/2026

One-way

Basic

From
$133

Low fares from Louisville to Knoxville

$

Louisville (SDF)to

Knoxville (TYS)
Depart: 04/25/2026

One-way

Basic

From
$133
Seen: 8 hrs ago

Louisville (SDF)to

Knoxville (TYS)
Depart: 05/29/2026

One-way

Basic

From
$154
Seen: 7 hrs ago

Louisville (SDF)to

Knoxville (TYS)
Depart: 04/25/2026

One-way

Choice

From
$170
Seen: 8 hrs ago

Louisville (SDF)to

Knoxville (TYS)
Depart: 05/29/2026

One-way

Choice

From
$189
Seen: 7 hrs ago

Louisville (SDF)to

Knoxville (TYS)
Depart: 04/09/2026

One-way

Basic

From
$219
Seen: 1 hour ago

Louisville (SDF)to

Knoxville (TYS)
Depart: 04/09/2026

One-way

Choice

From
$229
Seen: 1 hour ago

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Explore flights from Louisville to Knoxville

Mar 2026
From$278*
Seen: 16 hrs ago
One Way/Basic
Apr 2026
From$133*
Seen: 8 hrs ago
One Way/Basic
May 2026
From$154*
Seen: 7 hrs ago
One Way/Basic
$219
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    • Range$219-$278

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Louisville International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    189 miles

    Route Information

    32† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 32 weekly flights from Louisville to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Louisville to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Louisville to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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