Southwest® flights from Orange County/Santa Ana to Knoxville from $170

Promo Code

Low fares from Orange County/Santa Ana to Knoxville

$

Orange County/Santa Ana (SNA)to

Knoxville (TYS)
Depart: 04/18/2026

One-way

Basic

From
$170

Low fares from Orange County/Santa Ana to Knoxville

$

Orange County/Santa Ana (SNA)to

Knoxville (TYS)
Depart: 04/18/2026

One-way

Basic

From
$170
Seen: 12 hrs ago

Orange County/Santa Ana (SNA)to

Knoxville (TYS)
Depart: 04/18/2026

One-way

Choice

From
$210
Seen: 12 hrs ago

Orange County/Santa Ana (SNA)to

Knoxville (TYS)
Depart: 04/17/2026

One-way

Basic

From
$240
Seen: 12 hrs ago

Orange County/Santa Ana (SNA)to

Knoxville (TYS)
Depart: 04/08/2026

One-way

Basic

From
$250
Seen: 3 hrs ago

Orange County/Santa Ana (SNA)to

Knoxville (TYS)
Depart: 04/17/2026

One-way

Choice

From
$280
Seen: 12 hrs ago

Orange County/Santa Ana (SNA)to

Knoxville (TYS)
Depart: 04/18/2026

One-way

Choice Preferred

From
$290
Seen: 12 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Orange County/Santa Ana to Knoxville

Mar 2026
From$321*
Seen: 13 hrs ago
One Way/Basic
Apr 2026
From$170*
Seen: 12 hrs ago
One Way/Basic
May 2026
No result for this month.
$250
$549
Displaying fares for March-2026
  • 16

    Mon

    MAR

  • 17

    Tue

  • 18

    Wed

  • 19

    Thu

  • 20

    Fri

  • 21

    Sat

  • 22

    Sun

  • 23

    Mon

  • 24

    Tue

  • 25

    Wed

  • 26

    Thu

  • 27

    Fri

  • 28

    Sat

  • 29

    Sun

  • 30

    Mon

  • 31

    Tue

  • 01

    Wed

    APR

  • 02

    Thu

  • 03

    Fri

  • 04

    Sat

  • 05

    Sun

  • 06

    Mon

  • 07

    Tue

  • 08

    Wed

  • 09

    Thu

  • 10

    Fri

  • 11

    Sat

  • 12

    Sun

  • 13

    Mon

  • 14

    Tue

  • 15

    Wed

    • Range$250-$549

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    John Wayne Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    1924 miles

    Route Information

    27† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 27 weekly flights from Orange County/Santa Ana to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Orange County/Santa Ana to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Orange County/Santa Ana to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

    Explore Flights from Other Popular Origins

    Popular Flights from Orange County/Santa Ana