Southwest® flights from Panama City Beach, FL to Knoxville from $140

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Knoxville

Visit Knoxville


Book your flight to Knoxville and explore mountain views, live music, and nearby adventures in Gatlinburg and Pigeon Forge.

Flights available to book today. Service starts March 5, 2026.

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Low fares from Panama City Beach, FL to Knoxville

$

Panama City Beach, FL (ECP)to

Knoxville (TYS)
Depart: 09/26/2026

One-way

Basic

From
$140

Low fares from Panama City Beach, FL to Knoxville

$

Panama City Beach, FL (ECP)to

Knoxville (TYS)
Depart: 02/18/2026

One-way

Basic

From
$140
Seen: 11 hrs ago

Panama City Beach, FL (ECP)to

Knoxville (TYS)
Depart: 02/18/2026

One-way

Choice

From
$170
Seen: 11 hrs ago

Panama City Beach, FL (ECP)to

Knoxville (TYS)
Depart: 02/18/2026

One-way

Choice Preferred

From
$240
Seen: 11 hrs ago

Panama City Beach, FL (ECP)to

Knoxville (TYS)
Depart: 02/18/2026

One-way

Choice Extra

From
$280
Seen: 11 hrs ago

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Explore flights from Panama City Beach, FL to Knoxville

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Northwest Florida Beaches International Airport
Arriving at:
Mc Ghee Tyson Airport
Distance:
390 miles

Route Information

40† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 40 weekly flights from Panama City Beach, FL to Knoxville on Southwest Airlines.
To find the lowest fares by day and time to fly Panama City Beach, FL to Knoxville with Southwest, check out our Low Fare Calendar.
You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
Yes! Flights from Panama City Beach, FL to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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