Southwest® flights from St. Louis to Columbus from $108

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Low fares from St. Louis to Columbus

$

St. Louis (STL)to

Columbus (CMH)
Depart: 04/21/2026

One-way

Basic

From
$108
Seen: 13 hrs ago

St. Louis (STL)to

Columbus (CMH)
Depart: 04/14/2026

One-way

Basic

From
$108
Seen: 6 hrs ago

St. Louis (STL)to

Columbus (CMH)
Depart: 04/18/2026

One-way

Basic

From
$108
Seen: 6 hrs ago

St. Louis (STL)to

Columbus (CMH)
Depart: 04/15/2026

One-way

Basic

From
$108
Seen: 6 hrs ago

St. Louis (STL)to

Columbus (CMH)
Depart: 04/09/2026

One-way

Basic

From
$108
Seen: 45 minutes ago

St. Louis (STL)to

Columbus (CMH)
Depart: 04/27/2026

One-way

Basic

From
$108
Seen: 19 hrs ago

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Explore flights from St. Louis to Columbus

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Lambert-St Louis Int'l Airport
Arriving at:
Port Columbus International Airport
Average flight time:
1 hour 20 minutes
Distance:
409 miles

Route Information

156† Weekly flights
  • 2‡ Nonstop flights per day Monday through Friday
  • 1‡ Nonstop flight on Saturday
  • 2‡ Nonstop flights on Sunday

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

The average flight time from St. Louis to Columbus is 1 hour 20 minutes.
There are 156 weekly flights from St. Louis to Columbus on Southwest Airlines.
Yes, Southwest flies nonstop from St. Louis to Columbus 2 times per day from Monday through Friday.
Yes, Southwest flies nonstop from St. Louis to Columbus once per day on Saturdays and 2 times per day on Sundays.
To find the lowest fares by day and time to fly St. Louis to Columbus with Southwest, check out our Low Fare Calendar.
You can rent a car at Port Columbus International Airport book yours with your flight.
Yes! Flights from St. Louis to Columbus—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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