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Find low faresSouthwest® flights from St. Louis to Des Moines from $76
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1 Passenger
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Low fares from St. Louis to Des Moines
$
St. Louis (STL)to
Des Moines (DSM)
Depart: 04/14/2026
One-way
Basic
From
$76
Seen: 11 hrs ago
St. Louis (STL)to
Des Moines (DSM)
Depart: 04/30/2026
One-way
Basic
From
$101
Seen: 13 hrs ago
St. Louis (STL)to
Des Moines (DSM)
Depart: 04/14/2026
One-way
Choice
From
$106
Seen: 11 hrs ago
St. Louis (STL)to
Des Moines (DSM)
Depart: 04/30/2026
One-way
Choice
From
$131
Seen: 13 hrs ago
St. Louis (STL)to
Des Moines (DSM)
Depart: 03/12/2026
One-way
Basic
From
$161
Seen: 23 hrs ago
St. Louis (STL)to
Des Moines (DSM)
Depart: 03/24/2026
One-way
Basic
From
$164
Seen: 7 hrs ago
Explore flights from St. Louis to Des Moines
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Flight Details
Departing from:
Lambert-St Louis Int'l Airport
Arriving at:
Des Moines Airport
Average flight time:
1 hour 9 minutes
Distance:
259 miles
Route Information
22† Weekly flights
- 2‡ Nonstop flights per day Monday through Friday
- 1‡ Nonstop flight on Saturday
- 2‡ Nonstop flights on Sunday
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
The average flight time from St. Louis to Des Moines is 1 hour 9 minutes.
There are 22 weekly flights from St. Louis to Des Moines on Southwest Airlines.
Yes, Southwest flies nonstop from St. Louis to Des Moines 2 times per day from Monday through Friday.
Yes, Southwest flies nonstop from St. Louis to Des Moines once per day on Saturdays and 2 times per day on Sundays.
To find the lowest fares by day and time to fly St. Louis to Des Moines with Southwest, check out our Low Fare Calendar.
You can rent a car at Des Moines Airport book yours with your flight.
Yes! Flights from St. Louis to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.