Southwest® flights from St. Louis to Des Moines from $152

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Low fares from St. Louis to Des Moines

$

St. Louis (STL)to

Des Moines (DSM)
Depart: 12/05/2026

One-way

Basic

From
$152
Seen: 13 hrs ago

St. Louis (STL)to

Des Moines (DSM)
Depart: 12/22/2026

One-way

Basic

From
$152
Seen: 19 hrs ago

St. Louis (STL)to

Des Moines (DSM)
Depart: 12/09/2026

One-way

Basic

From
$152
Seen: 11 hrs ago

St. Louis (STL)to

Des Moines (DSM)
Depart: 12/01/2026

One-way

Basic

From
$152
Seen: 21 hrs ago

St. Louis (STL)to

Des Moines (DSM)
Depart: 12/30/2026

One-way

Basic

From
$152
Seen: 5 hrs ago

St. Louis (STL)to

Des Moines (DSM)
Depart: 02/01/2027

One-way

Basic

From
$167
Seen: 11 hrs ago

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Explore flights from St. Louis to Des Moines

Nov 2026
From$213*
Seen: 22 hrs ago
One Way/Basic
Dec 2026
From$152*
Seen: 19 hrs ago
One Way/Basic
Jan 2027
No result for this month.
cmp-daily-histogram-bars-legend-min-price-aria-label $152
cmp-daily-histogram-bars-legend-max-price-aria-label $418
Displaying fares for November-2026
  • STL–DSM, 11/10/2026: From $418
    10

    Tue

    NOV

  • STL–DSM, 11/11/2026: From $418
    11

    Wed

  • STL–DSM, 11/12/2026: From $275
    12

    Thu

  • STL–DSM, 11/13/2026: From $275
    13

    Fri

  • STL–DSM, 11/14/2026: From $275
    14

    Sat

  • STL–DSM, 11/15/2026: From $275
    15

    Sun

  • STL–DSM, 11/16/2026: From $275
    16

    Mon

  • STL–DSM, 11/17/2026: From $275
    17

    Tue

  • STL–DSM, 11/18/2026: From $275
    18

    Wed

  • STL–DSM, 11/19/2026: From $275
    19

    Thu

  • STL–DSM, 11/20/2026: From $275
    20

    Fri

  • STL–DSM: cmp-view-offers-disclaimer. Find Offers
    21

    Sat

  • STL–DSM: cmp-view-offers-disclaimer. Find Offers
    22

    Sun

  • STL–DSM: cmp-view-offers-disclaimer. Find Offers
    23

    Mon

  • STL–DSM, 11/24/2026: From $213
    24

    Tue

  • STL–DSM, 11/25/2026: From $213
    25

    Wed

  • STL–DSM: cmp-view-offers-disclaimer. Find Offers
    26

    Thu

  • STL–DSM: cmp-view-offers-disclaimer. Find Offers
    27

    Fri

  • STL–DSM: cmp-view-offers-disclaimer. Find Offers
    28

    Sat

  • STL–DSM: cmp-view-offers-disclaimer. Find Offers
    29

    Sun

  • STL–DSM, 11/30/2026: From $218
    30

    Mon

  • STL–DSM, 12/01/2026: From $152
    01

    Tue

    DEC

  • STL–DSM: cmp-view-offers-disclaimer. Find Offers
    02

    Wed

  • STL–DSM: cmp-view-offers-disclaimer. Find Offers
    03

    Thu

  • STL–DSM: cmp-view-offers-disclaimer. Find Offers
    04

    Fri

  • STL–DSM, 12/05/2026: From $152
    05

    Sat

  • STL–DSM: cmp-view-offers-disclaimer. Find Offers
    06

    Sun

  • STL–DSM: cmp-view-offers-disclaimer. Find Offers
    07

    Mon

  • STL–DSM: cmp-view-offers-disclaimer. Find Offers
    08

    Tue

  • STL–DSM, 12/09/2026: From $152
    09

    Wed

    • Range$152-$418

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Lambert-St Louis Int'l Airport
    Arriving at:
    Des Moines Airport
    Average flight time:
    1 hour 9 minutes
    Distance:
    259 miles

    Questions we hear the most

    The average flight time from St. Louis to Des Moines is 1 hour 9 minutes.
    There are 22 weekly flights from St. Louis to Des Moines on Southwest Airlines.
    Yes, Southwest flies nonstop from St. Louis to Des Moines 2 times per day from Monday through Friday.
    Yes, Southwest flies nonstop from St. Louis to Des Moines once per day on Saturdays and 2 times per day on Sundays.
    To find the lowest fares by day and time to fly St. Louis to Des Moines with Southwest, check out our Low Fare Calendar.
    You can rent a car at Des Moines Airport book yours with your flight.
    Yes! Flights from St. Louis to Des Moines—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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