Southwest® flights from Portland, ME to Buffalo/Niagara Falls from $107

Promo Code

Low fares from Portland, ME to Buffalo/Niagara Falls

$

Portland, ME (PWM)to

Buffalo/Niagara Falls (BUF)
Depart: 04/23/2026

One-way

Basic

From
$107
Seen: 11 hrs ago

Portland, ME (PWM)to

Buffalo/Niagara Falls (BUF)
Depart: 04/23/2026

One-way

Choice

From
$137
Seen: 11 hrs ago

Portland, ME (PWM)to

Buffalo/Niagara Falls (BUF)
Depart: 03/31/2026

One-way

Basic

From
$174
Seen: 6 hrs ago

Portland, ME (PWM)to

Buffalo/Niagara Falls (BUF)
Depart: 04/01/2026

One-way

Basic

From
$179
Seen: 6 hrs ago

Portland, ME (PWM)to

Buffalo/Niagara Falls (BUF)
Depart: 04/20/2026

One-way

Basic

From
$194
Seen: 12 hrs ago

Portland, ME (PWM)to

Buffalo/Niagara Falls (BUF)
Depart: 03/30/2026

One-way

Basic

From
$200
Seen: 6 hrs ago

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Explore flights from Portland, ME to Buffalo/Niagara Falls

Mar 2026
From$174*
Seen: 6 hrs ago
One Way/Basic
Apr 2026
From$107*
Seen: 11 hrs ago
One Way/Basic
May 2026
From$211*
Seen: 4 hrs ago
One Way/Basic
$174
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    • Range$174-$301

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Portland International Jetport
    Arriving at:
    Buffalo Niagara International Airport
    Distance:
    427 miles

    Route Information

    69† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 69 weekly flights from Portland, ME to Buffalo/Niagara Falls on Southwest Airlines.
    To find the lowest fares by day and time to fly Portland, ME to Buffalo/Niagara Falls with Southwest, check out our Low Fare Calendar.
    You can rent a car at Buffalo Niagara International Airport book yours with your flight.
    Yes! Flights from Portland, ME to Buffalo/Niagara Falls—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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