Southwest® flights from Portland, ME to San Diego from $209

Promo Code

Low fares from Portland, ME to San Diego

$

Portland, ME (PWM)to

San Diego (SAN)
Depart: 05/12/2026

One-way

Basic

From
$209
Seen: 1 hour ago

Portland, ME (PWM)to

San Diego (SAN)
Depart: 05/05/2026

One-way

Basic

From
$209
Seen: 3 hrs ago

Portland, ME (PWM)to

San Diego (SAN)
Depart: 04/13/2026

One-way

Basic

From
$211
Seen: 9 hrs ago

Portland, ME (PWM)to

San Diego (SAN)
Depart: 05/12/2026

One-way

Choice

From
$249
Seen: 1 hour ago

Portland, ME (PWM)to

San Diego (SAN)
Depart: 05/05/2026

One-way

Choice

From
$249
Seen: 3 hrs ago

Portland, ME (PWM)to

San Diego (SAN)
Depart: 04/11/2026

One-way

Basic

From
$249
Seen: 20 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Portland, ME to San Diego

Mar 2026
From$304*
Seen: 6 hrs ago
One Way/Basic
Apr 2026
From$211*
Seen: 9 hrs ago
One Way/Basic
May 2026
From$209*
Seen: 3 hrs ago
One Way/Basic
$249
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    • Range$249-$469

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Portland International Jetport
    Arriving at:
    San Diego International Airport
    Distance:
    2623 miles

    Route Information

    74† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 74 weekly flights from Portland, ME to San Diego on Southwest Airlines.
    To find the lowest fares by day and time to fly Portland, ME to San Diego with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Diego International Airport book yours with your flight.
    Yes! Flights from Portland, ME to San Diego—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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