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Find low faresSouthwest® flights from Portland, ME to San Diego from $197
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Low fares from Portland, ME to San Diego
$
Portland, ME (PWM)to
San Diego (SAN)
Depart: 05/06/2026
One-way
Basic
From
$195
Seen: 21 hrs ago
Portland, ME (PWM)to
San Diego (SAN)
Depart: 05/12/2026
One-way
Basic
From
$197
Seen: 13 hrs ago
Portland, ME (PWM)to
San Diego (SAN)
Depart: 04/23/2026
One-way
Basic
From
$197
Seen: 3 hrs ago
Portland, ME (PWM)to
San Diego (SAN)
Depart: 04/08/2026
One-way
Basic
From
$197
Seen: 10 hrs ago
Portland, ME (PWM)to
San Diego (SAN)
Depart: 04/25/2026
One-way
Basic
From
$197
Seen: 3 hrs ago
Portland, ME (PWM)to
San Diego (SAN)
Depart: 04/01/2026
One-way
Basic
From
$202
Seen: 3 hrs ago
Explore flights from Portland, ME to San Diego
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Flight Details
Departing from:
Portland International Jetport
Arriving at:
San Diego International Airport
Distance:
2623 miles
Route Information
74† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 74 weekly flights from Portland, ME to San Diego on Southwest Airlines.
To find the lowest fares by day and time to fly Portland, ME to San Diego with Southwest, check out our Low Fare Calendar.
You can rent a car at San Diego International Airport book yours with your flight.
Yes! Flights from Portland, ME to San Diego—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.