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Find low faresSouthwest® flights from Portland, ME to Louisville from $165
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1 Passenger
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Low fares from Portland, ME to Louisville
$
Portland, ME (PWM)to
Louisville (SDF)
Depart: 04/22/2026
One-way
Basic
From
$165
Seen: 18 hrs ago
Portland, ME (PWM)to
Louisville (SDF)
Depart: 04/22/2026
One-way
Choice
From
$200
Seen: 18 hrs ago
Portland, ME (PWM)to
Louisville (SDF)
Depart: 04/22/2026
One-way
Choice Preferred
From
$270
Seen: 18 hrs ago
Portland, ME (PWM)to
Louisville (SDF)
Depart: 04/22/2026
One-way
Choice Extra
From
$315
Seen: 18 hrs ago
Portland, ME (PWM)to
Louisville (SDF)
Depart: 02/12/2026
One-way
Choice
From
$349
Seen: 7 hrs ago
Portland, ME (PWM)to
Louisville (SDF)
Depart: 02/12/2026
One-way
Choice Preferred
From
$419
Seen: 7 hrs ago
Explore flights from Portland, ME to Louisville
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Flight Details
Departing from:
Portland International Jetport
Arriving at:
Louisville International Airport
Distance:
890 miles
Route Information
67† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 67 weekly flights from Portland, ME to Louisville on Southwest Airlines.
To find the lowest fares by day and time to fly Portland, ME to Louisville with Southwest, check out our Low Fare Calendar.
You can rent a car at Louisville International Airport book yours with your flight.
Yes! Flights from Portland, ME to Louisville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.