Southwest® flights from Portland, ME to Myrtle Beach from $149

Promo Code

Low fares from Portland, ME to Myrtle Beach

$

Portland, ME (PWM)to

Myrtle Beach (MYR)
Depart: 04/28/2026

One-way

Basic

From
$149
Seen: 5 hrs ago

Portland, ME (PWM)to

Myrtle Beach (MYR)
Depart: 05/16/2026

One-way

Basic

From
$154
Seen: 1 hour ago

Portland, ME (PWM)to

Myrtle Beach (MYR)
Depart: 04/07/2026

One-way

Basic

From
$160
Seen: 22 hrs ago

Portland, ME (PWM)to

Myrtle Beach (MYR)
Depart: 05/28/2026

One-way

Basic

From
$174
Seen: 16 hrs ago

Portland, ME (PWM)to

Myrtle Beach (MYR)
Depart: 04/13/2026

One-way

Basic

From
$178
Seen: 22 hrs ago

Portland, ME (PWM)to

Myrtle Beach (MYR)
Depart: 04/28/2026

One-way

Choice

From
$184
Seen: 5 hrs ago

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Find low fares

Explore flights from Portland, ME to Myrtle Beach

Mar 2026
From$359*
Seen: 12 hrs ago
One Way/Basic
Apr 2026
From$149*
Seen: 5 hrs ago
One Way/Basic
May 2026
From$154*
Seen: 1 hour ago
One Way/Basic
$160
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    • Range$160-$359

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Portland International Jetport
    Arriving at:
    Myrtle Beach International Airport
    Distance:
    830 miles

    Route Information

    63† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 63 weekly flights from Portland, ME to Myrtle Beach on Southwest Airlines.
    To find the lowest fares by day and time to fly Portland, ME to Myrtle Beach with Southwest, check out our Low Fare Calendar.
    You can rent a car at Myrtle Beach International Airport book yours with your flight.
    Yes! Flights from Portland, ME to Myrtle Beach—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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