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Find low faresSouthwest® flights from Portland, ME to San Francisco from $202
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1 Passenger
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Low fares from Portland, ME to San Francisco
$
Portland, ME (PWM)to
San Francisco (SFO)
Depart: 04/22/2026
One-way
Basic
From
$202
Seen: 17 hrs ago
Portland, ME (PWM)to
San Francisco (SFO)
Depart: 03/07/2026
One-way
Basic
From
$210
Seen: 20 hrs ago
Portland, ME (PWM)to
San Francisco (SFO)
Depart: 03/19/2026
One-way
Basic
From
$210
Seen: 14 hrs ago
Portland, ME (PWM)to
San Francisco (SFO)
Depart: 03/06/2026
One-way
Basic
From
$210
Seen: 20 hrs ago
Portland, ME (PWM)to
San Francisco (SFO)
Depart: 02/27/2026
One-way
Basic
From
$215
Seen: 13 hrs ago
Portland, ME (PWM)to
San Francisco (SFO)
Depart: 04/22/2026
One-way
Choice
From
$242
Seen: 17 hrs ago
Explore flights from Portland, ME to San Francisco
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Flight Details
Departing from:
Portland International Jetport
Arriving at:
San Francisco International Airport
Distance:
2723 miles
Route Information
45† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 45 weekly flights from Portland, ME to San Francisco on Southwest Airlines.
To find the lowest fares by day and time to fly Portland, ME to San Francisco with Southwest, check out our Low Fare Calendar.
You can rent a car at San Francisco International Airport book yours with your flight.
Yes! Flights from Portland, ME to San Francisco—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.