Southwest® flights from Detroit to Knoxville from $168

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Low fares from Detroit to Knoxville

$

Detroit (DTW)to

Knoxville (TYS)
Depart: 02/03/2027

One-way

Basic

From
$168

Low fares from Detroit to Knoxville

$

Detroit (DTW)to

Knoxville (TYS)
Depart: 02/03/2027

One-way

Basic

From
$168
Seen: 8 hrs ago

Detroit (DTW)to

Knoxville (TYS)
Depart: 02/03/2027

One-way

Choice

From
$203
Seen: 8 hrs ago

Detroit (DTW)to

Knoxville (TYS)
Depart: 12/04/2026

One-way

Basic

From
$203
Seen: 5 hrs ago

Detroit (DTW)to

Knoxville (TYS)
Depart: 12/23/2026

One-way

Basic

From
$209
Seen: 9 hrs ago

Detroit (DTW)to

Knoxville (TYS)
Depart: 12/03/2026

One-way

Basic

From
$229
Seen: 23 hrs ago

Detroit (DTW)to

Knoxville (TYS)
Depart: 12/05/2026

One-way

Basic

From
$229
Seen: 4 hrs ago

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Explore flights from Detroit to Knoxville

Nov 2026
From$232*
Seen: 1 hour ago
One Way/Basic
Dec 2026
From$203*
Seen: 5 hrs ago
One Way/Basic
Jan 2027
No result for this month.
cmp-daily-histogram-bars-legend-min-price-aria-label $203
cmp-daily-histogram-bars-legend-max-price-aria-label $501
Displaying fares for November-2026
  • DTW–TYS: cmp-view-offers-disclaimer. Find Offers
    13

    Fri

    NOV

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    14

    Sat

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    15

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    16

    Mon

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    17

    Tue

  • DTW–TYS, 11/18/2026: From $232
    18

    Wed

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    19

    Thu

  • DTW–TYS, 11/20/2026: From $501
    20

    Fri

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    21

    Sat

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    22

    Sun

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    23

    Mon

  • DTW–TYS, 11/24/2026: From $346
    24

    Tue

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    25

    Wed

  • DTW–TYS, 11/26/2026: From $237
    26

    Thu

  • DTW–TYS, 11/27/2026: From $232
    27

    Fri

  • DTW–TYS: cmp-view-offers-disclaimer. Find Offers
    28

    Sat

  • DTW–TYS, 11/29/2026: From $377
    29

    Sun

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    30

    Mon

  • DTW–TYS, 12/01/2026: From $232
    01

    Tue

    DEC

  • DTW–TYS: cmp-view-offers-disclaimer. Find Offers
    02

    Wed

  • DTW–TYS, 12/03/2026: From $229
    03

    Thu

  • DTW–TYS, 12/04/2026: From $203
    04

    Fri

  • DTW–TYS, 12/05/2026: From $229
    05

    Sat

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    06

    Sun

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    07

    Mon

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    08

    Tue

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    09

    Wed

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    10

    Thu

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    11

    Fri

  • DTW–TYS: cmp-view-offers-disclaimer. Find Offers
    12

    Sat

    • Range$203-$501

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Wayne County Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    443 miles

    Questions we hear the most

    There are 45 weekly flights from Detroit to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Detroit to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Detroit to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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