Southwest® flights from Greenville-Spartanburg to Knoxville from $219

Promo Code

Low fares from Greenville-Spartanburg to Knoxville

$

Greenville-Spartanburg (GSP)to

Knoxville (TYS)
Depart: 08/07/2026

One-way

Basic

From
$219

Low fares from Greenville-Spartanburg to Knoxville

$

Greenville-Spartanburg (GSP)to

Knoxville (TYS)
Depart: 08/07/2026

One-way

Basic

From
$219
Seen: 14 hrs ago

Greenville-Spartanburg (GSP)to

Knoxville (TYS)
Depart: 08/07/2026

One-way

Choice

From
$254
Seen: 14 hrs ago

Greenville-Spartanburg (GSP)to

Knoxville (TYS)
Depart: 08/07/2026

One-way

Choice Preferred

From
$324
Seen: 14 hrs ago

Greenville-Spartanburg (GSP)to

Knoxville (TYS)
Depart: 07/22/2026

One-way

Choice

From
$349
Seen: 1 hour ago

Greenville-Spartanburg (GSP)to

Knoxville (TYS)
Depart: 08/07/2026

One-way

Choice Extra

From
$364
Seen: 14 hrs ago

Greenville-Spartanburg (GSP)to

Knoxville (TYS)
Depart: 07/22/2026

One-way

Choice Preferred

From
$419
Seen: 1 hour ago

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Explore flights from Greenville-Spartanburg to Knoxville

Jul 2026
From$349*
Seen: 1 hour ago
One Way/Basic
Aug 2026
From$219*
Seen: 14 hrs ago
One Way/Basic
Sep 2026
No result for this month.
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    • Range$219-$349

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Greenville-Spartanburg International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    118 miles

    Route Information

    15† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 15 weekly flights from Greenville-Spartanburg to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Greenville-Spartanburg to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Greenville-Spartanburg to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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