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Find low faresSouthwest® flights from Myrtle Beach to Buffalo/Niagara Falls from $149
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1 Passenger
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Low fares from Myrtle Beach to Buffalo/Niagara Falls
$
Myrtle Beach (MYR)to
Buffalo/Niagara Falls (BUF)
Depart: 03/04/2026
One-way
Basic
From
$149
Seen: 14 hrs ago
Myrtle Beach (MYR)to
Buffalo/Niagara Falls (BUF)
Depart: 05/07/2026
One-way
Basic
From
$163
Seen: 19 hrs ago
Myrtle Beach (MYR)to
Buffalo/Niagara Falls (BUF)
Depart: 05/06/2026
One-way
Basic
From
$163
Seen: 19 hrs ago
Myrtle Beach (MYR)to
Buffalo/Niagara Falls (BUF)
Depart: 02/28/2026
One-way
Basic
From
$180
Seen: 14 hrs ago
Myrtle Beach (MYR)to
Buffalo/Niagara Falls (BUF)
Depart: 03/09/2026
One-way
Basic
From
$184
Seen: 11 hrs ago
Myrtle Beach (MYR)to
Buffalo/Niagara Falls (BUF)
Depart: 05/08/2026
One-way
Basic
From
$184
Seen: 19 hrs ago
Explore flights from Myrtle Beach to Buffalo/Niagara Falls
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Flight Details
Departing from:
Myrtle Beach International Airport
Arriving at:
Buffalo Niagara International Airport
Distance:
639 miles
Route Information
70† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 70 weekly flights from Myrtle Beach to Buffalo/Niagara Falls on Southwest Airlines.
To find the lowest fares by day and time to fly Myrtle Beach to Buffalo/Niagara Falls with Southwest, check out our Low Fare Calendar.
You can rent a car at Buffalo Niagara International Airport book yours with your flight.
Yes! Flights from Myrtle Beach to Buffalo/Niagara Falls—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.