Southwest® flights from Myrtle Beach to Louisville from $136

Promo Code

Low fares from Myrtle Beach to Louisville

$

Myrtle Beach (MYR)to

Louisville (SDF)
Depart: 04/15/2026

One-way

Basic

From
$136
Seen: 18 hrs ago

Myrtle Beach (MYR)to

Louisville (SDF)
Depart: 04/16/2026

One-way

Basic

From
$146
Seen: 18 hrs ago

Myrtle Beach (MYR)to

Louisville (SDF)
Depart: 04/15/2026

One-way

Choice

From
$166
Seen: 18 hrs ago

Myrtle Beach (MYR)to

Louisville (SDF)
Depart: 04/17/2026

One-way

Basic

From
$174
Seen: 4 hrs ago

Myrtle Beach (MYR)to

Louisville (SDF)
Depart: 04/16/2026

One-way

Choice

From
$176
Seen: 18 hrs ago

Myrtle Beach (MYR)to

Louisville (SDF)
Depart: 04/19/2026

One-way

Basic

From
$185
Seen: 5 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Myrtle Beach to Louisville

Mar 2026
From$369*
Seen: 22 hrs ago
One Way/Basic
Apr 2026
From$136*
Seen: 18 hrs ago
One Way/Basic
May 2026
No result for this month.
$369
Displaying fares for March-2026
  • 13

    Fri

    MAR

  • 14

    Sat

  • 15

    Sun

  • 16

    Mon

  • 17

    Tue

  • 18

    Wed

  • 19

    Thu

  • 20

    Fri

  • 21

    Sat

  • 22

    Sun

  • 23

    Mon

  • 24

    Tue

  • 25

    Wed

  • 26

    Thu

  • 27

    Fri

  • 28

    Sat

  • 29

    Sun

  • 30

    Mon

  • 31

    Tue

  • 01

    Wed

    APR

  • 02

    Thu

  • 03

    Fri

  • 04

    Sat

  • 05

    Sun

  • 06

    Mon

  • 07

    Tue

  • 08

    Wed

  • 09

    Thu

  • 10

    Fri

  • 11

    Sat

  • 12

    Sun

    • Range$369

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Myrtle Beach International Airport
    Arriving at:
    Louisville International Airport
    Distance:
    491 miles

    Route Information

    71† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 71 weekly flights from Myrtle Beach to Louisville on Southwest Airlines.
    To find the lowest fares by day and time to fly Myrtle Beach to Louisville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Louisville International Airport book yours with your flight.
    Yes! Flights from Myrtle Beach to Louisville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

    Explore Flights from Other Popular Origins

    Popular Flights from Myrtle Beach