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Find low faresSouthwest® flights from Myrtle Beach to St. Louis from $174
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1 Passenger
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Low fares from Myrtle Beach to St. Louis
$
Myrtle Beach (MYR)to
St. Louis (STL)
Depart: 04/11/2026
One-way
Basic
From
$174
Seen: 15 hrs ago
Myrtle Beach (MYR)to
St. Louis (STL)
Depart: 02/17/2026
One-way
Basic
From
$176
Seen: 10 hrs ago
Myrtle Beach (MYR)to
St. Louis (STL)
Depart: 02/19/2026
One-way
Basic
From
$176
Seen: 3 hrs ago
Myrtle Beach (MYR)to
St. Louis (STL)
Depart: 02/26/2026
One-way
Basic
From
$176
Seen: 17 hrs ago
Myrtle Beach (MYR)to
St. Louis (STL)
Depart: 02/11/2026
One-way
Basic
From
$176
Seen: 20 hrs ago
Myrtle Beach (MYR)to
St. Louis (STL)
Depart: 03/05/2026
One-way
Basic
From
$176
Seen: 8 hrs ago
Explore flights from Myrtle Beach to St. Louis
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Flight Details
Departing from:
Myrtle Beach International Airport
Arriving at:
Lambert-St Louis Int'l Airport
Average flight time:
2 hours 10 minutes
Distance:
728 miles
Route Information
83† Weekly flights
- 1‡ Nonstop flight on Saturday
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
The average flight time from Myrtle Beach to St. Louis is 2 hours 10 minutes.
There are 83 weekly flights from Myrtle Beach to St. Louis on Southwest Airlines.
Yes, Southwest flies nonstop from Myrtle Beach to St. Louis once per day on Saturdays.
To find the lowest fares by day and time to fly Myrtle Beach to St. Louis with Southwest, check out our Low Fare Calendar.
You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
Yes! Flights from Myrtle Beach to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.