Southwest® flights from Myrtle Beach to St. Louis from $167

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Low fares from Myrtle Beach to St. Louis

$

Myrtle Beach (MYR)to

St. Louis (STL)
Depart: 06/09/2026

One-way

Basic

From
$167
Seen: 16 hrs ago

Myrtle Beach (MYR)to

St. Louis (STL)
Depart: 04/07/2026

One-way

Basic

From
$172
Seen: 16 hrs ago

Myrtle Beach (MYR)to

St. Louis (STL)
Depart: 06/08/2026

One-way

Basic

From
$183
Seen: 16 hrs ago

Myrtle Beach (MYR)to

St. Louis (STL)
Depart: 04/25/2026

One-way

Basic

From
$183
Seen: 5 hrs ago

Myrtle Beach (MYR)to

St. Louis (STL)
Depart: 04/02/2026

One-way

Basic

From
$188
Seen: 23 hrs ago

Myrtle Beach (MYR)to

St. Louis (STL)
Depart: 06/20/2026

One-way

Basic

From
$190
Seen: 18 hrs ago

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Explore flights from Myrtle Beach to St. Louis

Mar 2026
From$190*
Seen: 15 hrs ago
One Way/Basic
Apr 2026
From$172*
Seen: 16 hrs ago
One Way/Basic
May 2026
From$190*
Seen: 5 hrs ago
One Way/Basic
$172
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    • Range$172-$265

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Myrtle Beach International Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Average flight time:
    2 hours 10 minutes
    Distance:
    728 miles

    Route Information

    83† Weekly flights
    • 1‡ Nonstop flight on Saturday

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    The average flight time from Myrtle Beach to St. Louis is 2 hours 10 minutes.
    There are 83 weekly flights from Myrtle Beach to St. Louis on Southwest Airlines.
    Yes, Southwest flies nonstop from Myrtle Beach to St. Louis once per day on Saturdays.
    To find the lowest fares by day and time to fly Myrtle Beach to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from Myrtle Beach to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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