Southwest® flights from Myrtle Beach to St. Louis from $156

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Low fares from Myrtle Beach to St. Louis

$

Myrtle Beach (MYR)to

St. Louis (STL)
Depart: 12/16/2026

One-way

Basic

From
$156
Seen: 15 hrs ago

Myrtle Beach (MYR)to

St. Louis (STL)
Depart: 12/03/2026

One-way

Basic

From
$156
Seen: 1 hour ago

Myrtle Beach (MYR)to

St. Louis (STL)
Depart: 12/01/2026

One-way

Basic

From
$156
Seen: 16 hrs ago

Myrtle Beach (MYR)to

St. Louis (STL)
Depart: 01/16/2027

One-way

Basic

From
$156
Seen: 7 hrs ago

Myrtle Beach (MYR)to

St. Louis (STL)
Depart: 01/18/2027

One-way

Basic

From
$162
Seen: 9 hrs ago

Myrtle Beach (MYR)to

St. Louis (STL)
Depart: 01/17/2027

One-way

Basic

From
$164
Seen: 7 hrs ago

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Explore flights from Myrtle Beach to St. Louis

Oct 2026
From$250*
Seen: 9 hrs ago
One Way/Basic
Nov 2026
From$250*
Seen: 9 hrs ago
One Way/Basic
Dec 2026
From$156*
Seen: 16 hrs ago
One Way/Basic
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Displaying fares for October-2026
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  • MYR–STL, 10/27/2026: From $250
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    • Range$250

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Myrtle Beach International Airport
    Arriving at:
    Lambert-St Louis Int'l Airport
    Average flight time:
    2 hours 10 minutes
    Distance:
    728 miles

    Questions we hear the most

    The average flight time from Myrtle Beach to St. Louis is 2 hours 10 minutes.
    There are 83 weekly flights from Myrtle Beach to St. Louis on Southwest Airlines.
    Yes, Southwest flies nonstop from Myrtle Beach to St. Louis once per day on Saturdays.
    To find the lowest fares by day and time to fly Myrtle Beach to St. Louis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Lambert-St Louis Int'l Airport book yours with your flight.
    Yes! Flights from Myrtle Beach to St. Louis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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