Southwest® flights from Myrtle Beach to Indianapolis from $136

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Low fares from Myrtle Beach to Indianapolis

$

Myrtle Beach (MYR)to

Indianapolis (IND)
Depart: 04/22/2026

One-way

Basic

From
$136
Seen: 22 hrs ago

Myrtle Beach (MYR)to

Indianapolis (IND)
Depart: 05/14/2026

One-way

Basic

From
$145
Seen: 19 hrs ago

Myrtle Beach (MYR)to

Indianapolis (IND)
Depart: 04/07/2026

One-way

Basic

From
$145
Seen: 3 hrs ago

Myrtle Beach (MYR)to

Indianapolis (IND)
Depart: 04/22/2026

One-way

Choice

From
$171
Seen: 22 hrs ago

Myrtle Beach (MYR)to

Indianapolis (IND)
Depart: 05/14/2026

One-way

Choice

From
$180
Seen: 19 hrs ago

Myrtle Beach (MYR)to

Indianapolis (IND)
Depart: 04/07/2026

One-way

Choice

From
$180
Seen: 3 hrs ago

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Explore flights from Myrtle Beach to Indianapolis

Mar 2026
From$299*
Seen: 11 hrs ago
One Way/Basic
Apr 2026
From$136*
Seen: 22 hrs ago
One Way/Basic
May 2026
From$145*
Seen: 19 hrs ago
One Way/Basic
$145
$389
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    • Range$145-$389

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Myrtle Beach International Airport
    Arriving at:
    Indianapolis International Airport
    Distance:
    583 miles

    Route Information

    66† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 66 weekly flights from Myrtle Beach to Indianapolis on Southwest Airlines.
    To find the lowest fares by day and time to fly Myrtle Beach to Indianapolis with Southwest, check out our Low Fare Calendar.
    You can rent a car at Indianapolis International Airport book yours with your flight.
    Yes! Flights from Myrtle Beach to Indianapolis—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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