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Find low faresSouthwest® flights from Myrtle Beach to Cleveland from $140
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Low fares from Myrtle Beach to Cleveland
$
Myrtle Beach (MYR)to
Cleveland (CLE)
Depart: 03/07/2026
One-way
Basic
From
$140
Seen: 11 hrs ago
Myrtle Beach (MYR)to
Cleveland (CLE)
Depart: 04/20/2026
One-way
Basic
From
$163
Seen: 10 hrs ago
Myrtle Beach (MYR)to
Cleveland (CLE)
Depart: 04/07/2026
One-way
Basic
From
$163
Seen: 1 hour ago
Myrtle Beach (MYR)to
Cleveland (CLE)
Depart: 04/23/2026
One-way
Basic
From
$163
Seen: 15 hrs ago
Myrtle Beach (MYR)to
Cleveland (CLE)
Depart: 03/07/2026
One-way
Choice
From
$175
Seen: 11 hrs ago
Myrtle Beach (MYR)to
Cleveland (CLE)
Depart: 03/19/2026
One-way
Basic
From
$184
Seen: 10 hrs ago
Explore flights from Myrtle Beach to Cleveland
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Flight Details
Departing from:
Myrtle Beach International Airport
Arriving at:
Hopkins International Airport
Distance:
557 miles
Route Information
75† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 75 weekly flights from Myrtle Beach to Cleveland on Southwest Airlines.
To find the lowest fares by day and time to fly Myrtle Beach to Cleveland with Southwest, check out our Low Fare Calendar.
You can rent a car at Hopkins International Airport book yours with your flight.
Yes! Flights from Myrtle Beach to Cleveland—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.