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Find low faresSouthwest® flights from Myrtle Beach to Chicago (Midway) from $139
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1 Passenger
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Low fares from Myrtle Beach to Chicago (Midway)
$
Myrtle Beach (MYR)to
Chicago (Midway) (MDW)
Depart: 05/09/2026
One-way
Basic
From
$134
Seen: 4 hrs ago
Myrtle Beach (MYR)to
Chicago (Midway) (MDW)
Depart: 02/25/2026
One-way
Basic
From
$139
Seen: 9 hrs ago
Myrtle Beach (MYR)to
Chicago (Midway) (MDW)
Depart: 02/21/2026
One-way
Basic
From
$152
Seen: 12 hrs ago
Myrtle Beach (MYR)to
Chicago (Midway) (MDW)
Depart: 02/23/2026
One-way
Basic
From
$152
Seen: 12 hrs ago
Myrtle Beach (MYR)to
Chicago (Midway) (MDW)
Depart: 03/07/2026
One-way
Basic
From
$152
Seen: 7 hrs ago
Myrtle Beach (MYR)to
Chicago (Midway) (MDW)
Depart: 03/28/2026
One-way
Basic
From
$152
Seen: 5 hrs ago
Explore flights from Myrtle Beach to Chicago (Midway)
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Flight Details
Departing from:
Myrtle Beach International Airport
Arriving at:
Chicago Midway International Airport
Average flight time:
2 hours 9 minutes
Distance:
738 miles
Route Information
100† Weekly flights
- 1‡ Nonstop flight per day Monday through Friday
- 1‡ Nonstop flight on Saturday
- 1‡ Nonstop flight on Sunday
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
The average flight time from Myrtle Beach to Chicago (Midway) is 2 hours 9 minutes.
There are 100 weekly flights from Myrtle Beach to Chicago (Midway) on Southwest Airlines.
Yes, Southwest flies nonstop from Myrtle Beach to Chicago (Midway) once per day from Monday through Friday.
Yes, Southwest flies nonstop from Myrtle Beach to Chicago (Midway) once per day on Saturdays and Sundays.
To find the lowest fares by day and time to fly Myrtle Beach to Chicago (Midway) with Southwest, check out our Low Fare Calendar.
You can rent a car at Chicago Midway International Airport book yours with your flight.
Yes! Flights from Myrtle Beach to Chicago (Midway)—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.