Southwest® flights from St. Louis to Knoxville from $127

Promo Code

Low fares from St. Louis to Knoxville

$

St. Louis (STL)to

Knoxville (TYS)
Depart: 11/12/2026

One-way

Basic

From
$127

Low fares from St. Louis to Knoxville

$

St. Louis (STL)to

Knoxville (TYS)
Depart: 11/12/2026

One-way

Basic

From
$127
Seen: 23 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 12/15/2026

One-way

Basic

From
$144
Seen: 19 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 11/18/2026

One-way

Basic

From
$144
Seen: 5 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 10/30/2026

One-way

Basic

From
$144
Seen: 10 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 11/10/2026

One-way

Basic

From
$144
Seen: 19 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 12/23/2026

One-way

Basic

From
$152
Seen: 1 hour ago

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Explore flights from St. Louis to Knoxville

Oct 2026
From$144*
Seen: 10 hrs ago
One Way/Basic
Nov 2026
From$127*
Seen: 23 hrs ago
One Way/Basic
Dec 2026
From$144*
Seen: 19 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $144
cmp-daily-histogram-bars-legend-max-price-aria-label $434
Displaying fares for October-2026
  • STL–TYS, 10/03/2026: From $271
    03

    Sat

    OCT

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    04

    Sun

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    05

    Mon

  • STL–TYS, 10/06/2026: From $434
    06

    Tue

  • STL–TYS, 10/07/2026: From $276
    07

    Wed

  • STL–TYS, 10/08/2026: From $354
    08

    Thu

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    09

    Fri

  • STL–TYS, 10/10/2026: From $271
    10

    Sat

  • STL–TYS, 10/11/2026: From $434
    11

    Sun

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    12

    Mon

  • STL–TYS, 10/13/2026: From $271
    13

    Tue

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    14

    Wed

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    15

    Thu

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    16

    Fri

  • STL–TYS, 10/17/2026: From $234
    17

    Sat

  • STL–TYS, 10/18/2026: From $234
    18

    Sun

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    19

    Mon

  • STL–TYS, 10/20/2026: From $234
    20

    Tue

  • STL–TYS, 10/21/2026: From $234
    21

    Wed

  • STL–TYS, 10/22/2026: From $253
    22

    Thu

  • STL–TYS, 10/23/2026: From $219
    23

    Fri

  • STL–TYS, 10/24/2026: From $160
    24

    Sat

  • STL–TYS, 10/25/2026: From $194
    25

    Sun

  • STL–TYS, 10/26/2026: From $152
    26

    Mon

  • STL–TYS, 10/27/2026: From $194
    27

    Tue

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    28

    Wed

  • STL–TYS, 10/29/2026: From $157
    29

    Thu

  • STL–TYS, 10/30/2026: From $144
    30

    Fri

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    31

    Sat

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    01

    Sun

    NOV

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    02

    Mon

    • Range$144-$434

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Lambert-St Louis Int'l Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    405 miles

    Route Information

    71† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 71 weekly flights from St. Louis to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly St. Louis to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from St. Louis to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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