Southwest® flights from St. Louis to Knoxville from $109

Promo Code

Low fares from St. Louis to Knoxville

$

St. Louis (STL)to

Knoxville (TYS)
Depart: 11/17/2026

One-way

Basic

From
$109

Low fares from St. Louis to Knoxville

$

St. Louis (STL)to

Knoxville (TYS)
Depart: 11/17/2026

One-way

Basic

From
$109
Seen: 12 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 11/18/2026

One-way

Basic

From
$109
Seen: 1 hour ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 11/10/2026

One-way

Basic

From
$109
Seen: 20 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 11/26/2026

One-way

Basic

From
$109
Seen: 8 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 12/09/2026

One-way

Basic

From
$109
Seen: 9 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 12/11/2026

One-way

Basic

From
$112
Seen: 3 hrs ago

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Explore flights from St. Louis to Knoxville

Oct 2026
From$281*
Seen: 15 hrs ago
One Way/Basic
Nov 2026
From$109*
Seen: 20 hrs ago
One Way/Basic
Dec 2026
From$109*
Seen: 9 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $109
cmp-daily-histogram-bars-legend-max-price-aria-label $389
Displaying fares for October-2026
  • STL–TYS, 10/23/2026: From $345
    23

    Fri

    OCT

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    24

    Sat

  • STL–TYS, 10/25/2026: From $345
    25

    Sun

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    26

    Mon

  • STL–TYS, 10/27/2026: From $281
    27

    Tue

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    28

    Wed

  • STL–TYS, 10/29/2026: From $339
    29

    Thu

  • STL–TYS, 10/30/2026: From $339
    30

    Fri

  • STL–TYS, 10/31/2026: From $281
    31

    Sat

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    01

    Sun

    NOV

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    02

    Mon

  • STL–TYS, 11/03/2026: From $281
    03

    Tue

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    04

    Wed

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    05

    Thu

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    06

    Fri

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    07

    Sat

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    08

    Sun

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    09

    Mon

  • STL–TYS, 11/10/2026: From $109
    10

    Tue

  • STL–TYS, 11/11/2026: From $114
    11

    Wed

  • STL–TYS, 11/12/2026: From $220
    12

    Thu

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    13

    Fri

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    14

    Sat

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    15

    Sun

  • STL–TYS, 11/16/2026: From $204
    16

    Mon

  • STL–TYS, 11/17/2026: From $109
    17

    Tue

  • STL–TYS, 11/18/2026: From $109
    18

    Wed

  • STL–TYS, 11/19/2026: From $339
    19

    Thu

  • STL–TYS, 11/20/2026: From $389
    20

    Fri

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    21

    Sat

  • STL–TYS, 11/22/2026: From $284
    22

    Sun

    • Range$109-$389

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Lambert-St Louis Int'l Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    405 miles

    Questions we hear the most

    There are 71 weekly flights from St. Louis to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly St. Louis to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from St. Louis to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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