Southwest® flights from St. Louis to Knoxville from $159

Promo Code

Low fares from St. Louis to Knoxville

$

St. Louis (STL)to

Knoxville (TYS)
Depart: 12/15/2026

One-way

Basic

From
$159

Low fares from St. Louis to Knoxville

$

St. Louis (STL)to

Knoxville (TYS)
Depart: 12/15/2026

One-way

Basic

From
$159
Seen: 14 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 12/05/2026

One-way

Basic

From
$159
Seen: 9 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 12/14/2026

One-way

Basic

From
$159
Seen: 23 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 01/06/2027

One-way

Basic

From
$159
Seen: 1 hour ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 12/21/2026

One-way

Basic

From
$159
Seen: 2 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 12/25/2026

One-way

Basic

From
$170
Seen: 11 minutes ago

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Explore flights from St. Louis to Knoxville

Nov 2026
From$249*
Seen: 3 hrs ago
One Way/Basic
Dec 2026
From$159*
Seen: 23 hrs ago
One Way/Basic
Jan 2027
From$159*
Seen: 1 hour ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $159
cmp-daily-histogram-bars-legend-max-price-aria-label $519
Displaying fares for November-2026
  • STL–TYS, 11/12/2026: From $350
    12

    Thu

    NOV

  • STL–TYS, 11/13/2026: From $350
    13

    Fri

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    14

    Sat

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    15

    Sun

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    16

    Mon

  • STL–TYS, 11/17/2026: From $286
    17

    Tue

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    18

    Wed

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    19

    Thu

  • STL–TYS, 11/20/2026: From $519
    20

    Fri

  • STL–TYS, 11/21/2026: From $286
    21

    Sat

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    22

    Sun

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    23

    Mon

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    24

    Tue

  • STL–TYS, 11/25/2026: From $249
    25

    Wed

  • STL–TYS, 11/26/2026: From $249
    26

    Thu

  • STL–TYS, 11/27/2026: From $249
    27

    Fri

  • STL–TYS, 11/28/2026: From $279
    28

    Sat

  • STL–TYS, 11/29/2026: From $419
    29

    Sun

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    30

    Mon

  • STL–TYS, 12/01/2026: From $249
    01

    Tue

    DEC

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    02

    Wed

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    03

    Thu

  • STL–TYS, 12/04/2026: From $234
    04

    Fri

  • STL–TYS, 12/05/2026: From $159
    05

    Sat

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    06

    Sun

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    07

    Mon

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    08

    Tue

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    09

    Wed

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    10

    Thu

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    11

    Fri

    • Range$159-$519

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Lambert-St Louis Int'l Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    405 miles

    Questions we hear the most

    There are 71 weekly flights from St. Louis to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly St. Louis to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from St. Louis to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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