Southwest® flights from St. Louis to Knoxville from $106

Promo Code

Low fares from St. Louis to Knoxville

$

St. Louis (STL)to

Knoxville (TYS)
Depart: 09/11/2026

One-way

Basic

From
$106

Low fares from St. Louis to Knoxville

$

St. Louis (STL)to

Knoxville (TYS)
Depart: 09/11/2026

One-way

Basic

From
$106
Seen: 17 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 09/30/2026

One-way

Basic

From
$124
Seen: 23 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 09/12/2026

One-way

Basic

From
$124
Seen: 22 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 08/31/2026

One-way

Basic

From
$124
Seen: 5 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 08/26/2026

One-way

Basic

From
$124
Seen: 9 hrs ago

St. Louis (STL)to

Knoxville (TYS)
Depart: 08/29/2026

One-way

Basic

From
$124
Seen: 1 hour ago

Looking for more low-fare flights?

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Explore flights from St. Louis to Knoxville

Aug 2026
From$124*
Seen: 5 hrs ago
One Way/Basic
Sep 2026
From$106*
Seen: 17 hrs ago
One Way/Basic
Oct 2026
From$140*
Seen: 12 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $124
cmp-daily-histogram-bars-legend-max-price-aria-label $325
Displaying fares for August-2026
  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    03

    Mon

    AUG

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    04

    Tue

  • STL–TYS, 08/05/2026: From $271
    05

    Wed

  • STL–TYS, 08/06/2026: From $325
    06

    Thu

  • STL–TYS, 08/07/2026: From $325
    07

    Fri

  • STL–TYS, 08/08/2026: From $261
    08

    Sat

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    09

    Sun

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    10

    Mon

  • STL–TYS, 08/11/2026: From $261
    11

    Tue

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    12

    Wed

  • STL–TYS, 08/13/2026: From $319
    13

    Thu

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    14

    Fri

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    15

    Sat

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    16

    Sun

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    17

    Mon

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    18

    Tue

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    19

    Wed

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    20

    Thu

  • STL–TYS, 08/21/2026: From $184
    21

    Fri

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    22

    Sat

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    23

    Sun

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    24

    Mon

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    25

    Tue

  • STL–TYS, 08/26/2026: From $124
    26

    Wed

  • STL–TYS, 08/27/2026: From $124
    27

    Thu

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    28

    Fri

  • STL–TYS, 08/29/2026: From $124
    29

    Sat

  • STL–TYS, 08/30/2026: From $184
    30

    Sun

  • STL–TYS, 08/31/2026: From $124
    31

    Mon

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    01

    Tue

    SEP

  • STL–TYS: cmp-view-offers-disclaimer. Find Offers
    02

    Wed

    • Range$124-$325

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Lambert-St Louis Int'l Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    405 miles

    Route Information

    71† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 71 weekly flights from St. Louis to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly St. Louis to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from St. Louis to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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