Looking for more low-fare flights?
Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.
Find low faresSouthwest® flights from Myrtle Beach to Chicago (O'Hare) from $185
expand_more
1 Passenger
expand_morePromo Code
expand_moretoday
today
Low fares from Myrtle Beach to Chicago (O'Hare)
$
Myrtle Beach (MYR)to
Chicago (Midway) (MDW)
Depart: 05/09/2026
One-way
Basic
From
$134
Seen: 3 hrs ago
Myrtle Beach (MYR)to
Chicago (Midway) (MDW)
Depart: 03/21/2026
One-way
Basic
From
$161
Seen: 13 hrs ago
Myrtle Beach (MYR)to
Chicago (Midway) (MDW)
Depart: 03/07/2026
One-way
Basic
From
$161
Seen: 13 hrs ago
Myrtle Beach (MYR)to
Chicago (Midway) (MDW)
Depart: 03/28/2026
One-way
Basic
From
$161
Seen: 13 hrs ago
Myrtle Beach (MYR)to
Chicago (Midway) (MDW)
Depart: 04/01/2026
One-way
Basic
From
$162
Seen: 13 hrs ago
Myrtle Beach (MYR)to
Chicago (Midway) (MDW)
Depart: 05/09/2026
One-way
Choice
From
$162
Seen: 3 hrs ago
Explore flights from Myrtle Beach to Chicago (O'Hare)
location_on
location_on
Flight Details
Departing from:
Myrtle Beach International Airport
Arriving at:
O'Hare International Airport
Distance:
753 miles
Route Information
40† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 40 weekly flights from Myrtle Beach to Chicago (O'Hare) on Southwest Airlines.
To find the lowest fares by day and time to fly Myrtle Beach to Chicago (O'Hare) with Southwest, check out our Low Fare Calendar.
You can rent a car at O'Hare International Airport book yours with your flight.
Yes! Flights from Myrtle Beach to Chicago (O'Hare)—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.