Southwest® flights from Myrtle Beach to Chicago (O'Hare)

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Low fares from Myrtle Beach to Chicago (O'Hare)

$

Myrtle Beach (MYR)to

Chicago (Midway) (MDW)
Depart: 10/01/2026

One-way

Basic

From
$99
Seen: 5 hrs ago

Myrtle Beach (MYR)to

Chicago (Midway) (MDW)
Depart: 10/21/2026

One-way

Basic

From
$99
Seen: 2 hrs ago

Myrtle Beach (MYR)to

Chicago (Midway) (MDW)
Depart: 10/15/2026

One-way

Basic

From
$99
Seen: 11 hrs ago

Myrtle Beach (MYR)to

Chicago (Midway) (MDW)
Depart: 10/28/2026

One-way

Basic

From
$99
Seen: 7 hrs ago

Myrtle Beach (MYR)to

Chicago (Midway) (MDW)
Depart: 10/07/2026

One-way

Basic

From
$99
Seen: 2 hrs ago

Myrtle Beach (MYR)to

Chicago (Midway) (MDW)
Depart: 10/14/2026

One-way

Basic

From
$99
Seen: 22 hrs ago

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Explore flights from Myrtle Beach to Chicago (O'Hare)

Aug 2026
From$208*
Seen: 2 hrs ago
One Way/Basic
Sep 2026
From$109*
Seen: 11 hrs ago
One Way/Basic
Oct 2026
From$99*
Seen: 22 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $109
cmp-daily-histogram-bars-legend-max-price-aria-label $389
Displaying fares for August-2026
  • MYR–MDW, 08/25/2026: From $208
    25

    Tue

    AUG

  • MYR–MDW, 08/26/2026: From $208
    26

    Wed

  • MYR–MDW, 08/27/2026: From $245
    27

    Thu

  • MYR–MDW, 08/28/2026: From $245
    28

    Fri

  • MYR–MDW, 08/29/2026: From $208
    29

    Sat

  • MYR–MDW, 08/30/2026: From $245
    30

    Sun

  • MYR–MDW, 08/31/2026: From $245
    31

    Mon

  • MYR–MDW, 09/01/2026: From $208
    01

    Tue

    SEP

  • MYR–MDW: cmp-view-offers-disclaimer. Find Offers
    02

    Wed

  • MYR–MDW, 09/03/2026: From $245
    03

    Thu

  • MYR–MDW, 09/04/2026: From $245
    04

    Fri

  • MYR–MDW, 09/05/2026: From $173
    05

    Sat

  • MYR–MDW: cmp-view-offers-disclaimer. Find Offers
    06

    Sun

  • MYR–MDW, 09/07/2026: From $389
    07

    Mon

  • MYR–MDW, 09/08/2026: From $294
    08

    Tue

  • MYR–MDW: cmp-view-offers-disclaimer. Find Offers
    09

    Wed

  • MYR–MDW, 09/10/2026: From $173
    10

    Thu

  • MYR–MDW: cmp-view-offers-disclaimer. Find Offers
    11

    Fri

  • MYR–MDW: cmp-view-offers-disclaimer. Find Offers
    12

    Sat

  • MYR–MDW, 09/13/2026: From $294
    13

    Sun

  • MYR–MDW, 09/14/2026: From $155
    14

    Mon

  • MYR–MDW, 09/15/2026: From $109
    15

    Tue

  • MYR–MDW: cmp-view-offers-disclaimer. Find Offers
    16

    Wed

  • MYR–MDW: cmp-view-offers-disclaimer. Find Offers
    17

    Thu

  • MYR–MDW, 09/18/2026: From $160
    18

    Fri

  • MYR–MDW, 09/19/2026: From $190
    19

    Sat

  • MYR–MDW, 09/20/2026: From $321
    20

    Sun

  • MYR–MDW, 09/21/2026: From $241
    21

    Mon

  • MYR–MDW: cmp-view-offers-disclaimer. Find Offers
    22

    Tue

  • MYR–MDW: cmp-view-offers-disclaimer. Find Offers
    23

    Wed

  • MYR–MDW: cmp-view-offers-disclaimer. Find Offers
    24

    Thu

    • Range$109-$389

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Myrtle Beach International Airport
    Arriving at:
    O'Hare International Airport
    Distance:
    753 miles

    Route Information

    40† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 40 weekly flights from Myrtle Beach to Chicago (O'Hare) on Southwest Airlines.
    To find the lowest fares by day and time to fly Myrtle Beach to Chicago (O'Hare) with Southwest, check out our Low Fare Calendar.
    You can rent a car at O'Hare International Airport book yours with your flight.
    Yes! Flights from Myrtle Beach to Chicago (O'Hare)—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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