Southwest® flights from Myrtle Beach to Midland/Odessa from $424

Promo Code

Low fares from Myrtle Beach to Midland/Odessa

$

Myrtle Beach (MYR)to

Midland/Odessa (MAF)
Depart: 03/04/2026

One-way

Choice

From
$424
Seen: 14 minutes ago

Myrtle Beach (MYR)to

Midland/Odessa (MAF)
Depart: 03/20/2026

One-way

Choice

From
$472
Seen: 8 hrs ago

Myrtle Beach (MYR)to

Midland/Odessa (MAF)
Depart: 03/04/2026

One-way

Choice Preferred

From
$504
Seen: 14 minutes ago

Myrtle Beach (MYR)to

Midland/Odessa (MAF)
Depart: 03/20/2026

One-way

Choice Preferred

From
$552
Seen: 8 hrs ago

Myrtle Beach (MYR)to

Midland/Odessa (MAF)
Depart: 03/04/2026

One-way

Choice Extra

From
$564
Seen: 14 minutes ago

Myrtle Beach (MYR)to

Midland/Odessa (MAF)
Depart: 03/20/2026

One-way

Choice Extra

From
$612
Seen: 8 hrs ago

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Explore flights from Myrtle Beach to Midland/Odessa

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Myrtle Beach International Airport
Arriving at:
Midland International Airport
Distance:
1357 miles

Route Information

32† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 32 weekly flights from Myrtle Beach to Midland/Odessa on Southwest Airlines.
To find the lowest fares by day and time to fly Myrtle Beach to Midland/Odessa with Southwest, check out our Low Fare Calendar.
You can rent a car at Midland International Airport book yours with your flight.
Yes! Flights from Myrtle Beach to Midland/Odessa—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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