Southwest® flights from Portland, ME to Knoxville from $159

Promo Code

Low fares from Portland, ME to Knoxville

$

Portland, ME (PWM)to

Knoxville (TYS)
Depart: 12/25/2026

One-way

Basic

From
$159

Low fares from Portland, ME to Knoxville

$

Portland, ME (PWM)to

Knoxville (TYS)
Depart: 12/25/2026

One-way

Basic

From
$159
Seen: 14 hrs ago

Portland, ME (PWM)to

Knoxville (TYS)
Depart: 11/03/2026

One-way

Basic

From
$164
Seen: 3 hrs ago

Portland, ME (PWM)to

Knoxville (TYS)
Depart: 12/25/2026

One-way

Choice

From
$199
Seen: 14 hrs ago

Portland, ME (PWM)to

Knoxville (TYS)
Depart: 11/03/2026

One-way

Choice

From
$204
Seen: 3 hrs ago

Portland, ME (PWM)to

Knoxville (TYS)
Depart: 11/02/2026

One-way

Basic

From
$264
Seen: 5 hrs ago

Portland, ME (PWM)to

Knoxville (TYS)
Depart: 12/25/2026

One-way

Choice Preferred

From
$269
Seen: 14 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

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Explore flights from Portland, ME to Knoxville

Oct 2026
From$405*
Seen: 13 hrs ago
One Way/Basic
Nov 2026
From$164*
Seen: 3 hrs ago
One Way/Basic
Dec 2026
From$159*
Seen: 14 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $164
Displaying fares for October-2026
  • PWM–TYS: cmp-view-offers-disclaimer. Find Offers
    12

    Mon

    OCT

  • PWM–TYS, 10/13/2026: From $410
    13

    Tue

  • PWM–TYS, 10/14/2026: From $405
    14

    Wed

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    15

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    17

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    18

    Sun

  • PWM–TYS, 10/19/2026: From $405
    19

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    20

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    21

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    22

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    23

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    24

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    25

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    26

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    27

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    28

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    29

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    30

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    31

    Sat

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    01

    Sun

    NOV

  • PWM–TYS, 11/02/2026: From $264
    02

    Mon

  • PWM–TYS, 11/03/2026: From $164
    03

    Tue

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    04

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    05

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    06

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    07

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    08

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    09

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    11

    Wed

    • Range$164-$410

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Portland International Jetport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    906 miles

    Questions we hear the most

    There are 35 weekly flights from Portland, ME to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Portland, ME to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Portland, ME to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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