Southwest® flights from Portland, ME to Knoxville from $214

Promo Code

Low fares from Portland, ME to Knoxville

$

Portland, ME (PWM)to

Knoxville (TYS)
Depart: 09/28/2026

One-way

Basic

From
$214

Low fares from Portland, ME to Knoxville

$

Portland, ME (PWM)to

Knoxville (TYS)
Depart: 09/28/2026

One-way

Basic

From
$214
Seen: 2 hrs ago

Portland, ME (PWM)to

Knoxville (TYS)
Depart: 07/21/2026

One-way

Basic

From
$244
Seen: 2 hrs ago

Portland, ME (PWM)to

Knoxville (TYS)
Depart: 09/28/2026

One-way

Choice

From
$254
Seen: 2 hrs ago

Portland, ME (PWM)to

Knoxville (TYS)
Depart: 08/11/2026

One-way

Basic

From
$270
Seen: 2 hrs ago

Portland, ME (PWM)to

Knoxville (TYS)
Depart: 07/24/2026

One-way

Basic

From
$284
Seen: 23 hrs ago

Portland, ME (PWM)to

Knoxville (TYS)
Depart: 07/21/2026

One-way

Choice

From
$284
Seen: 2 hrs ago

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Find low fares

Explore flights from Portland, ME to Knoxville

Jul 2026
From$244*
Seen: 2 hrs ago
One Way/Basic
Aug 2026
From$270*
Seen: 2 hrs ago
One Way/Basic
Sep 2026
From$214*
Seen: 2 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $244
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    • Range$244-$349

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Portland International Jetport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    906 miles

    Route Information

    35† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 35 weekly flights from Portland, ME to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Portland, ME to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Portland, ME to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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