Southwest® flights from Knoxville to Jacksonville from $118
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1 Passenger
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today
Low fares from Knoxville to Jacksonville
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$
Knoxville (TYS)to
Jacksonville (JAX)
Depart: 04/01/2026
One-way
Basic
From
$118
Low fares from Knoxville to Jacksonville
$
Knoxville (TYS)to
Jacksonville (JAX)
Depart: 04/01/2026
One-way
Basic
From
$118
Seen: 16 hrs ago
Knoxville (TYS)to
Jacksonville (JAX)
Depart: 04/07/2026
One-way
Basic
From
$118
Seen: 14 hrs ago
Knoxville (TYS)to
Jacksonville (JAX)
Depart: 04/15/2026
One-way
Basic
From
$118
Seen: 9 hrs ago
Knoxville (TYS)to
Jacksonville (JAX)
Depart: 04/16/2026
One-way
Basic
From
$123
Seen: 37 minutes ago
Knoxville (TYS)to
Jacksonville (JAX)
Depart: 03/10/2026
One-way
Basic
From
$130
Seen: 6 hrs ago
Knoxville (TYS)to
Jacksonville (JAX)
Depart: 04/17/2026
One-way
Basic
From
$140
Seen: 11 hrs ago
Explore flights from Knoxville to Jacksonville
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Flight Details
Departing from:
Mc Ghee Tyson Airport
Arriving at:
Jacksonville International Airport
Distance:
390 miles
Route Information
50† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 50 weekly flights from Knoxville to Jacksonville on Southwest Airlines.
To find the lowest fares by day and time to fly Knoxville to Jacksonville with Southwest, check out our Low Fare Calendar.
You can rent a car at Jacksonville International Airport book yours with your flight.
Yes! Flights from Knoxville to Jacksonville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.