Southwest® flights from Knoxville to Portland, ME from $166

Promo Code

Low fares from Knoxville to Portland, ME

$

Knoxville (TYS)to

Portland, ME (PWM)
Depart: 09/08/2026

One-way

Basic

From
$166

Low fares from Knoxville to Portland, ME

$

Knoxville (TYS)to

Portland, ME (PWM)
Depart: 07/08/2026

One-way

Basic

From
$166
Seen: 15 hrs ago

Knoxville (TYS)to

Portland, ME (PWM)
Depart: 06/09/2026

One-way

Basic

From
$171
Seen: 12 hrs ago

Knoxville (TYS)to

Portland, ME (PWM)
Depart: 08/12/2026

One-way

Basic

From
$171
Seen: 7 hrs ago

Knoxville (TYS)to

Portland, ME (PWM)
Depart: 07/22/2026

One-way

Basic

From
$171
Seen: 15 hrs ago

Knoxville (TYS)to

Portland, ME (PWM)
Depart: 07/03/2026

One-way

Basic

From
$175
Seen: 2 hrs ago

Knoxville (TYS)to

Portland, ME (PWM)
Depart: 07/08/2026

One-way

Choice

From
$206
Seen: 15 hrs ago

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Explore flights from Knoxville to Portland, ME

May 2026
From$260*
Seen: 14 hrs ago
One Way/Basic
Jun 2026
From$171*
Seen: 12 hrs ago
One Way/Basic
Jul 2026
From$166*
Seen: 15 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $171
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    • Range$171-$334

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    Portland International Jetport
    Distance:
    906 miles

    Route Information

    34† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 34 weekly flights from Knoxville to Portland, ME on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to Portland, ME with Southwest, check out our Low Fare Calendar.
    You can rent a car at Portland International Jetport book yours with your flight.
    Yes! Flights from Knoxville to Portland, ME—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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