Southwest® flights from Knoxville to Detroit from $132

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Low fares from Knoxville to Detroit

$

Knoxville (TYS)to

Detroit (DTW)
Depart: 04/15/2026

One-way

Basic

From
$132

Low fares from Knoxville to Detroit

$

Knoxville (TYS)to

Detroit (DTW)
Depart: 04/15/2026

One-way

Basic

From
$132
Seen: 14 hrs ago

Knoxville (TYS)to

Detroit (DTW)
Depart: 04/18/2026

One-way

Basic

From
$141
Seen: 14 hrs ago

Knoxville (TYS)to

Detroit (DTW)
Depart: 04/15/2026

One-way

Choice

From
$162
Seen: 14 hrs ago

Knoxville (TYS)to

Detroit (DTW)
Depart: 04/18/2026

One-way

Choice

From
$171
Seen: 14 hrs ago

Knoxville (TYS)to

Detroit (DTW)
Depart: 04/16/2026

One-way

Basic

From
$189
Seen: 14 hrs ago

Knoxville (TYS)to

Detroit (DTW)
Depart: 04/30/2026

One-way

Basic

From
$189
Seen: 21 hrs ago

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Explore flights from Knoxville to Detroit

*Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

Flight Details

Departing from:
Mc Ghee Tyson Airport
Arriving at:
Wayne County Airport
Distance:
443 miles

Route Information

43† Weekly flights

† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

Questions we hear the most

There are 43 weekly flights from Knoxville to Detroit on Southwest Airlines.
To find the lowest fares by day and time to fly Knoxville to Detroit with Southwest, check out our Low Fare Calendar.
You can rent a car at Wayne County Airport book yours with your flight.
Yes! Flights from Knoxville to Detroit—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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