Southwest® flights from Knoxville to San Diego from $193

Promo Code

Low fares from Knoxville to San Diego

$

Knoxville (TYS)to

San Diego (SAN)
Depart: 12/05/2026

One-way

Basic

From
$193

Low fares from Knoxville to San Diego

$

Knoxville (TYS)to

San Diego (SAN)
Depart: 12/05/2026

One-way

Basic

From
$193
Seen: 17 hrs ago

Knoxville (TYS)to

San Diego (SAN)
Depart: 01/05/2027

One-way

Basic

From
$193
Seen: 9 hrs ago

Knoxville (TYS)to

San Diego (SAN)
Depart: 02/09/2027

One-way

Basic

From
$193
Seen: 7 hrs ago

Knoxville (TYS)to

San Diego (SAN)
Depart: 12/02/2026

One-way

Basic

From
$193
Seen: 14 hrs ago

Knoxville (TYS)to

San Diego (SAN)
Depart: 12/08/2026

One-way

Basic

From
$193
Seen: 5 hrs ago

Knoxville (TYS)to

San Diego (SAN)
Depart: 12/10/2026

One-way

Basic

From
$208
Seen: 20 hrs ago

Looking for more low-fare flights?

Check out the Low Fare Calendar to find a fare that works for you. Just choose the month you want to depart and return, and we’ll show you the best fares available.

Find low fares

Explore flights from Knoxville to San Diego

Nov 2026
From$316*
Seen: 2 hrs ago
One Way/Basic
Dec 2026
From$193*
Seen: 14 hrs ago
One Way/Basic
Jan 2027
From$193*
Seen: 9 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $193
cmp-daily-histogram-bars-legend-max-price-aria-label $786
Displaying fares for November-2026
  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    09

    Mon

    NOV

  • TYS–SAN, 11/10/2026: From $316
    10

    Tue

  • TYS–SAN, 11/11/2026: From $316
    11

    Wed

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    12

    Thu

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    13

    Fri

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    14

    Sat

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    15

    Sun

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    16

    Mon

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    17

    Tue

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    18

    Wed

  • TYS–SAN, 11/19/2026: From $396
    19

    Thu

  • TYS–SAN, 11/20/2026: From $396
    20

    Fri

  • TYS–SAN, 11/21/2026: From $316
    21

    Sat

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    22

    Sun

  • TYS–SAN, 11/23/2026: From $319
    23

    Mon

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    24

    Tue

  • TYS–SAN, 11/25/2026: From $316
    25

    Wed

  • TYS–SAN, 11/26/2026: From $324
    26

    Thu

  • TYS–SAN, 11/27/2026: From $369
    27

    Fri

  • TYS–SAN, 11/28/2026: From $549
    28

    Sat

  • TYS–SAN, 11/29/2026: From $786
    29

    Sun

  • TYS–SAN, 11/30/2026: From $407
    30

    Mon

  • TYS–SAN, 12/01/2026: From $297
    01

    Tue

    DEC

  • TYS–SAN, 12/02/2026: From $193
    02

    Wed

  • TYS–SAN, 12/03/2026: From $208
    03

    Thu

  • TYS–SAN, 12/04/2026: From $218
    04

    Fri

  • TYS–SAN, 12/05/2026: From $193
    05

    Sat

  • TYS–SAN, 12/06/2026: From $279
    06

    Sun

  • TYS–SAN, 12/07/2026: From $208
    07

    Mon

  • TYS–SAN, 12/08/2026: From $193
    08

    Tue

    • Range$193-$786

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    San Diego International Airport
    Distance:
    1902 miles

    Questions we hear the most

    There are 62 weekly flights from Knoxville to San Diego on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to San Diego with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Diego International Airport book yours with your flight.
    Yes! Flights from Knoxville to San Diego—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

    Explore Flights from Other Popular Origins

    Popular Flights from Knoxville