Southwest® flights from Knoxville to San Diego from $140

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Low fares from Knoxville to San Diego

$

Knoxville (TYS)to

San Diego (SAN)
Depart: 02/08/2027

One-way

Basic

From
$140

Low fares from Knoxville to San Diego

$

Knoxville (TYS)to

San Diego (SAN)
Depart: 11/17/2026

One-way

Basic

From
$140
Seen: 23 hrs ago

Knoxville (TYS)to

San Diego (SAN)
Depart: 01/11/2027

One-way

Basic

From
$140
Seen: 4 hrs ago

Knoxville (TYS)to

San Diego (SAN)
Depart: 11/10/2026

One-way

Basic

From
$140
Seen: 15 hrs ago

Knoxville (TYS)to

San Diego (SAN)
Depart: 01/27/2027

One-way

Basic

From
$140
Seen: 19 hrs ago

Knoxville (TYS)to

San Diego (SAN)
Depart: 11/09/2026

One-way

Basic

From
$140
Seen: 23 hrs ago

Knoxville (TYS)to

San Diego (SAN)
Depart: 11/15/2026

One-way

Basic

From
$174
Seen: 21 hrs ago

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Explore flights from Knoxville to San Diego

Oct 2026
From$311*
Seen: 15 hrs ago
One Way/Basic
Nov 2026
From$140*
Seen: 15 hrs ago
One Way/Basic
Dec 2026
From$216*
Seen: 3 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $140
cmp-daily-histogram-bars-legend-max-price-aria-label $447
Displaying fares for October-2026
  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    21

    Wed

    OCT

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    22

    Thu

  • TYS–SAN, 10/23/2026: From $391
    23

    Fri

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    24

    Sat

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    25

    Sun

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    26

    Mon

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    27

    Tue

  • TYS–SAN, 10/28/2026: From $311
    28

    Wed

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    29

    Thu

  • TYS–SAN, 10/30/2026: From $391
    30

    Fri

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    31

    Sat

  • TYS–SAN, 11/01/2026: From $391
    01

    Sun

    NOV

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    02

    Mon

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    03

    Tue

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    04

    Wed

  • TYS–SAN, 11/05/2026: From $314
    05

    Thu

  • TYS–SAN, 11/06/2026: From $314
    06

    Fri

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    07

    Sat

  • TYS–SAN, 11/08/2026: From $447
    08

    Sun

  • TYS–SAN, 11/09/2026: From $140
    09

    Mon

  • TYS–SAN, 11/10/2026: From $140
    10

    Tue

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    11

    Wed

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    12

    Thu

  • TYS–SAN, 11/13/2026: From $174
    13

    Fri

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    14

    Sat

  • TYS–SAN, 11/15/2026: From $174
    15

    Sun

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    16

    Mon

  • TYS–SAN, 11/17/2026: From $140
    17

    Tue

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    18

    Wed

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    19

    Thu

  • TYS–SAN: cmp-view-offers-disclaimer. Find Offers
    20

    Fri

    • Range$140-$447

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    San Diego International Airport
    Distance:
    1902 miles

    Questions we hear the most

    There are 62 weekly flights from Knoxville to San Diego on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to San Diego with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Diego International Airport book yours with your flight.
    Yes! Flights from Knoxville to San Diego—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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