Southwest® flights from Knoxville to Manchester, NH from $161

Promo Code

Low fares from Knoxville to Manchester, NH

$

Knoxville (TYS)to

Manchester, NH (MHT)
Depart: 05/12/2026

One-way

Basic

From
$161

Low fares from Knoxville to Manchester, NH

$

Knoxville (TYS)to

Manchester, NH (MHT)
Depart: 05/12/2026

One-way

Basic

From
$161
Seen: 9 hrs ago

Knoxville (TYS)to

Manchester, NH (MHT)
Depart: 05/09/2026

One-way

Basic

From
$176
Seen: 17 hrs ago

Knoxville (TYS)to

Manchester, NH (MHT)
Depart: 05/12/2026

One-way

Choice

From
$201
Seen: 9 hrs ago

Knoxville (TYS)to

Manchester, NH (MHT)
Depart: 05/09/2026

One-way

Choice

From
$216
Seen: 17 hrs ago

Knoxville (TYS)to

Manchester, NH (MHT)
Depart: 04/08/2026

One-way

Basic

From
$254
Seen: 16 hrs ago

Knoxville (TYS)to

Manchester, NH (MHT)
Depart: 05/12/2026

One-way

Choice Preferred

From
$271
Seen: 9 hrs ago

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Explore flights from Knoxville to Manchester, NH

Apr 2026
From$254*
Seen: 16 hrs ago
One Way/Basic
May 2026
From$161*
Seen: 9 hrs ago
One Way/Basic
Jun 2026
No result for this month.
$254
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    • Range$254-$492

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    Manchester-Boston Regional Airport
    Distance:
    831 miles

    Route Information

    41† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 41 weekly flights from Knoxville to Manchester, NH on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to Manchester, NH with Southwest, check out our Low Fare Calendar.
    You can rent a car at Manchester-Boston Regional Airport book yours with your flight.
    Yes! Flights from Knoxville to Manchester, NH—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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