Southwest® flights from Knoxville to San Antonio from $109
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1 Passenger
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today
Low fares from Knoxville to San Antonio
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$
Knoxville (TYS)to
San Antonio (SAT)
Depart: 04/14/2026
One-way
Basic
From
$109
Low fares from Knoxville to San Antonio
$
Knoxville (TYS)to
San Antonio (SAT)
Depart: 04/14/2026
One-way
Basic
From
$109
Seen: 8 hrs ago
Knoxville (TYS)to
San Antonio (SAT)
Depart: 04/13/2026
One-way
Basic
From
$123
Seen: 8 hrs ago
Knoxville (TYS)to
San Antonio (SAT)
Depart: 04/14/2026
One-way
Choice
From
$144
Seen: 8 hrs ago
Knoxville (TYS)to
San Antonio (SAT)
Depart: 04/13/2026
One-way
Choice
From
$158
Seen: 8 hrs ago
Knoxville (TYS)to
San Antonio (SAT)
Depart: 05/11/2026
One-way
Basic
From
$179
Seen: 10 hrs ago
Knoxville (TYS)to
San Antonio (SAT)
Depart: 05/07/2026
One-way
Basic
From
$184
Seen: 10 hrs ago
Explore flights from Knoxville to San Antonio
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Flight Details
Departing from:
Mc Ghee Tyson Airport
Arriving at:
San Antonio International Airport
Distance:
947 miles
Route Information
57† Weekly flights
† Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.
‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.
Questions we hear the most
There are 57 weekly flights from Knoxville to San Antonio on Southwest Airlines.
To find the lowest fares by day and time to fly Knoxville to San Antonio with Southwest, check out our Low Fare Calendar.
You can rent a car at San Antonio International Airport book yours with your flight.
Yes! Flights from Knoxville to San Antonio—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
Check the status of your upcoming Southwest flight.
Check out the Southwest Airlines® Help Center for answers about everything Southwest.