Southwest® flights from Knoxville to San Antonio from $132

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Low fares from Knoxville to San Antonio

$

Knoxville (TYS)to

San Antonio (SAT)
Depart: 12/05/2026

One-way

Basic

From
$132

Low fares from Knoxville to San Antonio

$

Knoxville (TYS)to

San Antonio (SAT)
Depart: 12/05/2026

One-way

Basic

From
$132
Seen: 15 hrs ago

Knoxville (TYS)to

San Antonio (SAT)
Depart: 11/03/2026

One-way

Basic

From
$132
Seen: 1 hour ago

Knoxville (TYS)to

San Antonio (SAT)
Depart: 11/04/2026

One-way

Basic

From
$132
Seen: 1 hour ago

Knoxville (TYS)to

San Antonio (SAT)
Depart: 11/11/2026

One-way

Basic

From
$132
Seen: 18 hrs ago

Knoxville (TYS)to

San Antonio (SAT)
Depart: 12/17/2026

One-way

Basic

From
$132
Seen: 13 hrs ago

Knoxville (TYS)to

San Antonio (SAT)
Depart: 11/10/2026

One-way

Basic

From
$132
Seen: 3 minutes ago

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Explore flights from Knoxville to San Antonio

Oct 2026
From$184*
Seen: 2 hrs ago
One Way/Basic
Nov 2026
From$132*
Seen: 1 hour ago
One Way/Basic
Dec 2026
From$132*
Seen: 13 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $132
cmp-daily-histogram-bars-legend-max-price-aria-label $351
Displaying fares for October-2026
  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    09

    Fri

    OCT

  • TYS–SAT, 10/10/2026: From $305
    10

    Sat

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    11

    Sun

  • TYS–SAT, 10/12/2026: From $351
    12

    Mon

  • TYS–SAT, 10/13/2026: From $305
    13

    Tue

  • TYS–SAT, 10/14/2026: From $305
    14

    Wed

  • TYS–SAT, 10/15/2026: From $351
    15

    Thu

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    16

    Fri

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    17

    Sat

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    18

    Sun

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    19

    Mon

  • TYS–SAT, 10/20/2026: From $305
    20

    Tue

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    21

    Wed

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    22

    Thu

  • TYS–SAT, 10/23/2026: From $254
    23

    Fri

  • TYS–SAT, 10/24/2026: From $219
    24

    Sat

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    25

    Sun

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    26

    Mon

  • TYS–SAT, 10/27/2026: From $214
    27

    Tue

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    28

    Wed

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    29

    Thu

  • TYS–SAT, 10/30/2026: From $184
    30

    Fri

  • TYS–SAT, 10/31/2026: From $214
    31

    Sat

  • TYS–SAT, 11/01/2026: From $240
    01

    Sun

    NOV

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    02

    Mon

  • TYS–SAT, 11/03/2026: From $132
    03

    Tue

  • TYS–SAT, 11/04/2026: From $132
    04

    Wed

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    05

    Thu

  • TYS–SAT, 11/06/2026: From $184
    06

    Fri

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    07

    Sat

  • TYS–SAT: cmp-view-offers-disclaimer. Find Offers
    08

    Sun

    • Range$132-$351

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Mc Ghee Tyson Airport
    Arriving at:
    San Antonio International Airport
    Distance:
    947 miles

    Questions we hear the most

    There are 57 weekly flights from Knoxville to San Antonio on Southwest Airlines.
    To find the lowest fares by day and time to fly Knoxville to San Antonio with Southwest, check out our Low Fare Calendar.
    You can rent a car at San Antonio International Airport book yours with your flight.
    Yes! Flights from Knoxville to San Antonio—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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