Southwest® flights from Myrtle Beach to Knoxville from $141

Promo Code

Low fares from Myrtle Beach to Knoxville

$

Myrtle Beach (MYR)to

Knoxville (TYS)
Depart: 10/13/2026

One-way

Basic

From
$124

Low fares from Myrtle Beach to Knoxville

$

Myrtle Beach (MYR)to

Knoxville (TYS)
Depart: 09/11/2026

One-way

Basic

From
$141
Seen: 3 hrs ago

Myrtle Beach (MYR)to

Knoxville (TYS)
Depart: 09/11/2026

One-way

Choice

From
$176
Seen: 3 hrs ago

Myrtle Beach (MYR)to

Knoxville (TYS)
Depart: 07/20/2026

One-way

Basic

From
$224
Seen: 11 hrs ago

Myrtle Beach (MYR)to

Knoxville (TYS)
Depart: 09/11/2026

One-way

Choice Preferred

From
$246
Seen: 3 hrs ago

Myrtle Beach (MYR)to

Knoxville (TYS)
Depart: 07/20/2026

One-way

Choice

From
$259
Seen: 11 hrs ago

Myrtle Beach (MYR)to

Knoxville (TYS)
Depart: 09/11/2026

One-way

Choice Extra

From
$286
Seen: 3 hrs ago

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Explore flights from Myrtle Beach to Knoxville

Jul 2026
From$224*
Seen: 11 hrs ago
One Way/Basic
Aug 2026
No result for this month.
Sep 2026
From$141*
Seen: 3 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $224
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    • Range$224-$344

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Myrtle Beach International Airport
    Arriving at:
    Mc Ghee Tyson Airport
    Distance:
    323 miles

    Route Information

    23† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 23 weekly flights from Myrtle Beach to Knoxville on Southwest Airlines.
    To find the lowest fares by day and time to fly Myrtle Beach to Knoxville with Southwest, check out our Low Fare Calendar.
    You can rent a car at Mc Ghee Tyson Airport book yours with your flight.
    Yes! Flights from Myrtle Beach to Knoxville—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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