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Southwest® flights from Des Moines to Orange County/Santa Ana from $130

Promo Code

Low fares from Des Moines to Orange County/Santa Ana

$

Des Moines (DSM)to

Orange County/Santa Ana (SNA)
Depart: 06/09/2026

One-way

Basic

From
$130
Seen: 7 hrs ago

Des Moines (DSM)to

Orange County/Santa Ana (SNA)
Depart: 06/06/2026

One-way

Basic

From
$166
Seen: 13 hrs ago

Des Moines (DSM)to

Orange County/Santa Ana (SNA)
Depart: 06/09/2026

One-way

Choice

From
$175
Seen: 7 hrs ago

Des Moines (DSM)to

Orange County/Santa Ana (SNA)
Depart: 07/28/2026

One-way

Basic

From
$175
Seen: 6 hrs ago

Des Moines (DSM)to

Orange County/Santa Ana (SNA)
Depart: 07/29/2026

One-way

Basic

From
$176
Seen: 6 hrs ago

Des Moines (DSM)to

Orange County/Santa Ana (SNA)
Depart: 06/23/2026

One-way

Basic

From
$210
Seen: 11 hrs ago

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Explore flights from Des Moines to Orange County/Santa Ana

May 2026
From$240*
Seen: 10 hrs ago
One Way/Basic
Jun 2026
From$130*
Seen: 7 hrs ago
One Way/Basic
Jul 2026
From$175*
Seen: 6 hrs ago
One Way/Basic
cmp-daily-histogram-bars-legend-min-price-aria-label $130
cmp-daily-histogram-bars-legend-max-price-aria-label $534
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    • Range$130-$534

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    John Wayne Airport
    Distance:
    1429 miles

    Route Information

    65† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 65 weekly flights from Des Moines to Orange County/Santa Ana on Southwest Airlines.
    To find the lowest fares by day and time to fly Des Moines to Orange County/Santa Ana with Southwest, check out our Low Fare Calendar.
    You can rent a car at John Wayne Airport book yours with your flight.
    Yes! Flights from Des Moines to Orange County/Santa Ana—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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