Southwest® flights from Des Moines to Panama City Beach, FL from $178

Promo Code

Low fares from Des Moines to Panama City Beach, FL

$

Des Moines (DSM)to

Panama City Beach, FL (ECP)
Depart: 05/09/2026

One-way

Basic

From
$178
Seen: 19 hrs ago

Des Moines (DSM)to

Panama City Beach, FL (ECP)
Depart: 04/25/2026

One-way

Basic

From
$188
Seen: 2 hrs ago

Des Moines (DSM)to

Panama City Beach, FL (ECP)
Depart: 04/06/2026

One-way

Basic

From
$193
Seen: 5 hrs ago

Des Moines (DSM)to

Panama City Beach, FL (ECP)
Depart: 06/11/2026

One-way

Basic

From
$204
Seen: 45 minutes ago

Des Moines (DSM)to

Panama City Beach, FL (ECP)
Depart: 05/09/2026

One-way

Choice

From
$213
Seen: 19 hrs ago

Des Moines (DSM)to

Panama City Beach, FL (ECP)
Depart: 04/25/2026

One-way

Choice

From
$223
Seen: 2 hrs ago

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Explore flights from Des Moines to Panama City Beach, FL

Mar 2026
From$249*
Seen: 18 hrs ago
One Way/Basic
Apr 2026
From$188*
Seen: 2 hrs ago
One Way/Basic
May 2026
From$178*
Seen: 19 hrs ago
One Way/Basic
$193
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    • Range$193-$410

    *Fares displayed have been collected within the last 24 hours and may no longer be available at time of booking. Additional fees and charges for optional products and services may apply. Modifying this information may result in a different fare. To find the most updated fare, please visit Southwest.com. Fares listed are Basic, which are subject to additional terms and conditions.

    Flight Details

    Departing from:
    Des Moines Airport
    Arriving at:
    Northwest Florida Beaches International Airport
    Distance:
    887 miles

    Route Information

    31† Weekly flights

    † Weekly flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025. Note: route may not operate every day of the week.

    ‡ Nonstop flights based on DOT published scheduled average flights Monday through Sunday between 9/1/2025 and 9/30/2025.

    Questions we hear the most

    There are 31 weekly flights from Des Moines to Panama City Beach, FL on Southwest Airlines.
    To find the lowest fares by day and time to fly Des Moines to Panama City Beach, FL with Southwest, check out our Low Fare Calendar.
    You can rent a car at Northwest Florida Beaches International Airport book yours with your flight.
    Yes! Flights from Des Moines to Panama City Beach, FL—or from here or there to anywhere—can be changed with no change fees. Fare difference may apply.
    Check the status of your upcoming Southwest flight.
    Check out the Southwest Airlines® Help Center for answers about everything Southwest.

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